Potent and selective M1 muscarinic receptor allosteric agonist (EC50 = 198 nM). Binds to the orthosteric ACh site at high concentrations to act as an antagonist. Reverses contextual fear conditioning deficits. Shows cognitive enhancing actions. Blood-brain barrier permeable.
Solubility & Handling
Storage instructions
+4°C
Solubility overview
Soluble in water (25mM) or DMSO (5mM)
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Novel allosteric agonists of M1 muscarinic acetylcholine receptors induce brain region-specific responses that correspond with behavioral effects in animal models.
Digby GJ et al (2012) J Neurosci 32(25) : 8532-44.
Discovery and characterization of novel subtype-selective allosteric agonists for the investigation of M(1) receptor function in the central nervous system.
Lebois EP et al (2010) ACS Chem Neurosci 1(2) : 104-121.
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