Potent and selective M1 muscarinic receptor allosteric agonist (EC50 = 198 nM). Binds to the orthosteric ACh site at high concentrations to act as an antagonist. Reverses contextual fear conditioning deficits. Shows cognitive enhancing actions. Blood-brain barrier permeable.
Solubility & Handling
Solubility overview
Soluble in water (25mM) or DMSO (5mM)
Storage instructions
+4°C
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Novel allosteric agonists of M1 muscarinic acetylcholine receptors induce brain region-specific responses that correspond with behavioral effects in animal models.
Digby GJ et al (2012) J Neurosci 32(25) : 8532-44.
Discovery and characterization of novel subtype-selective allosteric agonists for the investigation of M(1) receptor function in the central nervous system.
Lebois EP et al (2010) ACS Chem Neurosci 1(2) : 104-121.
![VU 0357017 hydrochloride [1135242-13-5] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb1498.png "VU 0357017 hydrochloride [1135242-13-5]")
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