Product overview

Name VU 0361737
Description mGlu4 positive allosteric modulator
Purity >99%
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Biological Data

Biological description mGlu4 receptor positive allosteric modulator (EC50 = 0.24 µM). Displays little activity at mGlu5 and mGlu8 receptors and no activity at mGlu1, 2, 3, 6 and 7 receptors. Blood-brain barrier permeable.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Chemical name N-(4-Chloro-3-methoxyphenyl)-2-pyridinecarboxamide
Molecular Weight 262.69
Chemical structure VU 0361737  [1161205-04-4] Chemical Structure
Molecular Formula C13H11ClN2O2
CAS Number 1161205-04-4
PubChem identifier 44191096
SMILES ClC1=C(OC)C=C(NC(C2=NC=CC=C2)=O)C=C1
InChiKey ARYUXFNGXHNNDM-UHFFFAOYSA-N

References for VU 0361737

References are publications that support the biological activity of the product
  • Radiosynthesis of N-(4-chloro-3-[(11)C]methoxyphenyl)-2-picolinamide ([(11)C]ML128) as a PET radiotracer for metabotropic glutamate receptor subtype 4 (mGlu4).

    Kil KE et al (2013) Bioorg Med Chem 21(19) : 5955-62.
  • Discovery, synthesis, and structure-activity relationship development of a series of N-(4-acetamido)phenylpicolinamides as positive allosteric modulators of metabotropic glutamate receptor 4 (mGlu(4)) with CNS exposure in rats.

    Engers DW et al (2011) J Med Chem 54(4) : 1106-10.
  • Synthesis and evaluation of a series of heterobiarylamides that are centrally penetrant metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulators (PAMs).

    Engers DW et al (2009) J Med Chem 52(14) : 4115-8.