YM 298198 hydrochloride

Name: YM 298198 hydrochloride
Brand: Hello Bio
SKU: HB0664
Price: 216 USD
Availability: InStock

(HB0664)

Publications (2)

Technical documents: SDS CoA Datasheet

Product overview

Name

YM 298198 hydrochloride

Alternative names

YM 298198

Purity

>99%

Description

Potent, selective, non-competitive mGlu₁ antagonist

Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (3) Publications (2) References (3) Frequently bought together

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Images

YM 298198 hydrochloride product vial image | Hello Bio

Biological Data

Biological description

Potent, selective and non-competitive mGlu₁ receptor antagonist (IC₅₀ = 16 nM). Shows antiproliferative effects in cancers expressing mGlu₁ receptor.

Solubility & Handling

Solubility overview

Soluble in water (100mM)

Storage instructions

+4°C (desiccate)

Storage of solutions

Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.

Shipping Conditions

Stable for ambient temperature shipping. Follow storage instructions on receipt.

Important

This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

More Info

Dilution

More Info

Chemical Data

Purity

>99%

Chemical name

6-Amino-N-cyclohexyl-N,3-dimethylthiazolo[3,2-a]benzimidazole-2-carboxamide hydrochloride

Molecular Weight

378.92

Chemical structure

Molecular Formula

C₁₈H₂₂N₄OS.HCl

CAS Number

748758-45-4

PubChem identifier

45073464

SMILES

CC1=C(SC2=NC3=C(N12)C=C(C=C3)N)C(=O)N(C)C4CCCCC4.Cl

InChi

InChI=1S/C18H22N4OS.ClH/c1-11-16(17(23)21(2)13-6-4-3-5-7-13)24-18-20-14-9-8-12(19)10-15(14)22(11)18;/h8-10,13H,3-7,19H2,1-2H3;1H

InChiKey

WYTJVUVCSUWZTH-UHFFFAOYSA-N

MDL number

MFCD08703122

Technical guides

Metabotropic glutamate receptor (mGluR) mini-review

mGlu receptor (mGluR) associated proteins mini-review

Understanding purity and quality - a guide for life scientists (159.4 KB)

References for YM 298198 hydrochloride

References are publications that support the biological activity of the product

Metabotropic glutamate receptor-1 as a novel target for the antiangiogenic treatment of breast cancer.
Speyer CL et al (2014) PLoS One 9(3) : e88830.
Read more (PubMedID: 24633367)
Potent and specific action of the mGlu1 antagonists YM-298198 and JNJ16259685 on synaptic transmission in rat cerebellar slices.
Fukunaga I et al (2007) Br J Pharmacol 151(6) : 870-6.
Read more (PubMedID: 17502847)
Radioligand binding properties and pharmacological characterization of 6-amino-N-cyclohexyl-N,3-dimethylthiazolo[3,2-a]benzimidazole-2-carboxamide (YM-298198), a high-affinity, selective, and noncompetitive antagonist of metabotropic glutamate receptor ty
Kohara A et al (2005) J Pharmacol Exp Ther 315(1) : 163-9.
Read more (PubMedID: 15976016)

Publications

Submit Yours Now

These publications cite the use of YM 298198 hydrochloride purchased from Hello Bio:

Activity-dependent somatodendritic dopamine release in the substantia nigra autoinhibits the releasing neuron
Hikima T et al (2021) Cell Rep 35(1) : 108951
PubMedID: 33826884
The Probability of Neurotransmitter Release Governs AMPA Receptor Trafficking via Activity-Dependent Regulation of mGluR1 Surface Expression.
Sanderson et al (2018) Cell Rep. 25(13) : 3631-3646
PubMedID: 30590038

Potent, selective, non-competitive mGlu₁ antagonist

Order: HB0664
Pack	Price	Qty
10mg	$216
50mg	$858

YM 298198 hydrochloride

Product overview

Images

Biological Data

Solubility & Handling

Calculators

Molarity

Dilution

Chemical Data

Technical guides

References for YM 298198 hydrochloride

Metabotropic glutamate receptor-1 as a novel target for the antiangiogenic treatment of breast cancer.

Potent and specific action of the mGlu1 antagonists YM-298198 and JNJ16259685 on synaptic transmission in rat cerebellar slices.

Radioligand binding properties and pharmacological characterization of 6-amino-N-cyclohexyl-N,3-dimethylthiazolo[3,2-a]benzimidazole-2-carboxamide (YM-298198), a high-affinity, selective, and noncompetitive antagonist of metabotropic glutamate receptor ty

Activity-dependent somatodendritic dopamine release in the substantia nigra autoinhibits the releasing neuron

The Probability of Neurotransmitter Release Governs AMPA Receptor Trafficking via Activity-Dependent Regulation of mGluR1 Surface Expression.

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Tell us about your publication!

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YM 298198 hydrochloride

Product overview

Images

YM 298198 hydrochloride product vial image | Hello Bio

Biological Data

Solubility & Handling

Calculators

Molarity

Dilution

Chemical Data

Technical guides

References for YM 298198 hydrochloride

Metabotropic glutamate receptor-1 as a novel target for the antiangiogenic treatment of breast cancer.

Potent and specific action of the mGlu1 antagonists YM-298198 and JNJ16259685 on synaptic transmission in rat cerebellar slices.

Radioligand binding properties and pharmacological characterization of 6-amino-N-cyclohexyl-N,3-dimethylthiazolo[3,2-a]benzimidazole-2-carboxamide (YM-298198), a high-affinity, selective, and noncompetitive antagonist of metabotropic glutamate receptor ty

Activity-dependent somatodendritic dopamine release in the substantia nigra autoinhibits the releasing neuron

The Probability of Neurotransmitter Release Governs AMPA Receptor Trafficking via Activity-Dependent Regulation of mGluR1 Surface Expression.

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Tell us about your publication!

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