YM 298198 hydrochloride

Technical documents: SDS CoA Datasheet

Product overview

Name YM 298198 hydrochloride
Alternative names YM 298198
Purity >99%
Description Potent, selective, non-competitive mGlu1 antagonist
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YM 298198 hydrochloride product vial image | Hello Bio

Biological Data

Biological description Potent, selective and non-competitive mGlu1 receptor antagonist (IC50 = 16 nM). Shows antiproliferative effects in cancers expressing mGlu1 receptor.

Solubility & Handling

Storage instructions +4°C (desiccate)
Solubility overview Soluble in water (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >99%
Chemical name 6-Amino-N-cyclohexyl-N,3-dimethylthiazolo[3,2-a]benzimidazole-2-carboxamide hydrochloride
Molecular Weight 378.92
Chemical structure YM 298198 hydrochloride  [748758-45-4] Chemical Structure
Molecular Formula C18H22N4OS.HCl
CAS Number 748758-45-4
PubChem identifier 45073464
InChi InChI=1S/C18H22N4OS.ClH/c1-11-16(17(23)21(2)13-6-4-3-5-7-13)24-18-20-14-9-8-12(19)10-15(14)22(11)18;/h8-10,13H,3-7,19H2,1-2H3;1H
MDL number MFCD08703122

References for YM 298198 hydrochloride

References are publications that support the biological activity of the product
  • Metabotropic glutamate receptor-1 as a novel target for the antiangiogenic treatment of breast cancer.

    Speyer CL et al (2014) PLoS One 9(3) : e88830.
  • Potent and specific action of the mGlu1 antagonists YM-298198 and JNJ16259685 on synaptic transmission in rat cerebellar slices.

    Fukunaga I et al (2007) Br J Pharmacol 151(6) : 870-6.
  • Radioligand binding properties and pharmacological characterization of 6-amino-N-cyclohexyl-N,3-dimethylthiazolo[3,2-a]benzimidazole-2-carboxamide (YM-298198), a high-affinity, selective, and noncompetitive antagonist of metabotropic glutamate receptor ty

    Kohara A et al (2005) J Pharmacol Exp Ther 315(1) : 163-9.

3 Item(s)

These publications cite the use of YM 298198 hydrochloride purchased from Hello Bio:
  • Activity-dependent somatodendritic dopamine release in the substantia nigra autoinhibits the releasing neuron

    Hikima T et al (2021) Cell Rep 35(1) : 108951
    PubMedID: 33826884
  • The Probability of Neurotransmitter Release Governs AMPA Receptor Trafficking via Activity-Dependent Regulation of mGluR1 Surface Expression.

    Sanderson et al (2018) Cell Rep. 25(13) : 3631-3646
    PubMedID: 30590038

2 Item(s)