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Images YM 298198 hydrochloride product vial image | Hello Bio
YM 298198 hydrochloride product vial image | Hello Bio Biological Data Biological description Potent, selective and non-competitive mGlu1 receptor antagonist (IC50 = 16 nM). Shows antiproliferative effects in cancers expressing mGlu1 receptor.
Solubility & Handling Storage instructions +4°C (desiccate)
Solubility overview Soluble in water (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name 6-Amino-N -cyclohexyl-N,3-dimethylthiazolo[3,2-a ]benzimidazole-2-carboxamide hydrochloride
Chemical structure
Molecular Formula C18 H22 N4 OS.HCl
PubChem identifier 45073464
SMILES CC1=C(SC2=NC3=C(N12)C=C(C=C3)N)C(=O)N(C)C4CCCCC4.Cl
InChi InChI=1S/C18H22N4OS.ClH/c1-11-16(17(23)21(2)13-6-4-3-5-7-13)24-18-20-14-9-8-12(19)10-15(14)22(11)18;/h8-10,13H,3-7,19H2,1-2H3;1H
InChiKey WYTJVUVCSUWZTH-UHFFFAOYSA-N
References for YM 298198 hydrochloride References are publications that support the biological activity of the product
Metabotropic glutamate receptor-1 as a novel target for the antiangiogenic treatment of breast cancer. Speyer CL et al (2014) PLoS One 9(3) : e88830. Potent and specific action of the mGlu1 antagonists YM-298198 and JNJ16259685 on synaptic transmission in rat cerebellar slices. Fukunaga I et al (2007) Br J Pharmacol 151(6) : 870-6. Radioligand binding properties and pharmacological characterization of 6-amino-N-cyclohexyl-N,3-dimethylthiazolo[3,2-a]benzimidazole-2-carboxamide (YM-298198), a high-affinity, selective, and noncompetitive antagonist of metabotropic glutamate receptor ty Kohara A et al (2005) J Pharmacol Exp Ther 315(1) : 163-9.
Publications
These publications cite the use of YM 298198 hydrochloride purchased from Hello Bio:
Activity-dependent somatodendritic dopamine release in the substantia nigra autoinhibits the releasing neuron Hikima T et al (2021) Cell Rep 35(1) : 108951 The Probability of Neurotransmitter Release Governs AMPA Receptor Trafficking via Activity-Dependent Regulation of mGluR1 Surface Expression. Sanderson et al (2018) Cell Rep. 25(13) : 3631-3646
Potent, selective, non-competitive mGlu1 antagonist
![YM 298198 hydrochloride [748758-45-4] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0664.png "YM 298198 hydrochloride [748758-45-4]")
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