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Biological Data

Biological description Novel, selective mGlu7 receptor antagonist. Shows novel molecular mode of pharmacological action. Acts as an orthosteric like antagonist and binds at a binding pocket in the Venus flytrap domain. Inhibits long term potentiation (LTP) in the lateral amygdala in a mGlu7 dependent manner (IC50 = 88 nM). Shows anti-stress, anxiolytic and anti-depressant actions. Blood-brain barrier permeable.

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in DMSO (100mM) and in ethanol (20mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Chemical Data

Chemical name 7-Hydroxy-3-(4-iodophenoxy)-4H-1-benzopyran-4-one
Molecular Weight 380.13
Chemical structure XAP 044  [196928-50-4] Chemical Structure
Molecular Formula C15H9IO4
CAS Number 196928-50-4
PubChem identifier 5428913
SMILES C1=CC(=CC=C1OC2=COC3=C(C2=O)C=CC(=C3)O)I
InChi InChI=1S/C15H9IO4/c16-9-1-4-11(5-2-9)20-14-8-19-13-7-10(17)3-6-12(13)15(14)18/h1-8,17H
InChiKey XXZKJJYWINSUMJ-UHFFFAOYSA-N
MDL number MFCD00525548

References for XAP044

References are publications that support the biological activity of the product
  • Blocking metabotropic glutamate receptor subtype 7 (mGlu7) via the Venus flytrap domain (VFTD) inhibits amygdala plasticity, stress, and anxiety-related behavior.

    Gee CE et al (2014) J Biol Chem 289(16) : 10975-87.