Novel, selective mGlu7 receptor antagonist. Shows novel molecular mode of pharmacological action. Acts as an orthosteric like antagonist and binds at a binding pocket in the Venus flytrap domain. Inhibits long term potentiation (LTP) in the lateral amygdala in a mGlu7 dependent manner (IC50 = 88 nM). Shows anti-stress, anxiolytic and anti-depressant actions. Blood-brain barrier permeable.
Solubility & Handling
Soluble in DMSO (100mM) and in ethanol (20mM)
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.