Product overview
| Name | XAP044 |
| Purity | >98% |
| Description | Novel, selective mGlu7 antagonist |
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Biological Data
| Biological description | Novel, selective mGlu7 receptor antagonist. Shows novel molecular mode of pharmacological action. Acts as an orthosteric like antagonist and binds at a binding pocket in the Venus flytrap domain. Inhibits long term potentiation (LTP) in the lateral amygdala in a mGlu7 dependent manner (IC50 = 88 nM). Shows anti-stress, anxiolytic and anti-depressant actions. Blood-brain barrier permeable. |
Solubility & Handling
| Solubility overview | Soluble in DMSO (100mM) and in ethanol (20mM) |
| Storage instructions | -20°C |
| Storage of solutions | Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use. |
| Shipping Conditions | Stable for ambient temperature shipping. Follow storage instructions on receipt. |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Purity | >98% |
| Chemical name | 7-Hydroxy-3-(4-iodophenoxy)-4H-1-benzopyran-4-one |
| Molecular Weight | 380.13 |
| Chemical structure | ![XAP 044 [196928-50-4] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb1599.png "XAP 044 [196928-50-4]") |
| Molecular Formula | C15H9IO4 |
| CAS Number | 196928-50-4 |
| PubChem identifier | 5428913 |
| SMILES | C1=CC(=CC=C1OC2=COC3=C(C2=O)C=CC(=C3)O)I |
| InChi | InChI=1S/C15H9IO4/c16-9-1-4-11(5-2-9)20-14-8-19-13-7-10(17)3-6-12(13)15(14)18/h1-8,17H |
| InChiKey | XXZKJJYWINSUMJ-UHFFFAOYSA-N |
| MDL number | MFCD00525548 |
Technical guides
Understanding purity and quality - a guide for life scientistsReferences for XAP044
References are publications that support the biological activity of the product
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Blocking metabotropic glutamate receptor subtype 7 (mGlu7) via the Venus flytrap domain (VFTD) inhibits amygdala plasticity, stress, and anxiety-related behavior.
Gee CE et al (2014) J Biol Chem 289(16) : 10975-87.
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