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Designer receptors exclusively activated by designer drugs (DREADDs) are genetically engineered GPCRs that are activated by physiologically inert synthetic small molecules (designer drugs) but not their endogenous ligand. Read our DREADDs mini-review or for practical advice on using these ligands in the lab see Stability of Water-Soluble DREADD Ligands in Solution: A Technical Review and Clozapine N-Oxide (freebase) - a technical review on stability, solubility and use in the lab).
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Skyrin (HB4088)
Description:Selective glucagon receptor antagonist. Non-peptidic anti-diabetic agent
Purity:>97%
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Spiperone hydrochloride (HB1656)
Description:Selective D2-like receptor antagonist. 5-HT2A antagonist.
Purity:>98%
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(S)-(-)-Sulpiride (HB1836)
Description:Selective D2-like receptor antagonist. Active enantiomer.
Purity:>99%
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(RS)-(±)-Sulpiride (HB1835)
Description:Standard D2-like dopamine receptor antagonist
Purity:>98%
