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EHNA hydrochloride

(HB3540)
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Product overview

Name EHNA hydrochloride
Purity >98%
Description Potent adenosine deaminase and PDE2 inhibitor. Supresses spontaneous hESC differentiation. Also maintains pluripotency of hESCs in the absence of exogenous cytokines.
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (2) Reviews References (3)
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Biological Data

Biological description Potent adenosine deaminase (ADA) and PDE2 inhibitor (Ki = 1.6 nM at ADA and IC50 values are 0.8 and 4 ΜM at human and porcine PDE2 respectively. Reversibly supresses spontaneous hESCs differentiation. Also acts as a strong blocker of directed neuronal differentiation. Also maintains pluripotency of hESCs in the absence of exogenous cytokines.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in water (100mM) or DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name erythro-9-(2-Hydroxy-3-nonyl)adenin e hydrochloride
Molecular Weight 313.83
Chemical structure EHNA hydrochloride | [58337-38-5] Chemical Structure
Molecular Formula C14H23N5O.HCl
CAS Number 58337-38-5
PubChem identifier 11056106
SMILES NC1=NC=NC2=C1N=CN2[C@@H](CCCCCC)[C@H](O)C.Cl
InChiKey VVDXNJRUNJMYOZ-DHXVBOOMSA-N

References for EHNA hydrochloride

References are publications that support the biological activity of the product

  • Erythro-9-(2-hydroxy-3-nonyl)adenine (EHNA) blocks differentiation and maintains the expression of pluripotency markers in human embryonic stem cells.

    Burton et al (2010) Biochem J 432(3) : 575-84
    Read more (PubMedID: 20923411)

  • Probing the active site of adenosine deaminase by a pH responsive fluorescent competitive inhibitor.

    Caiolfa et al (1998) Biophys Chem 70(1) : 41-56
    Read more (PubMedID: 9474762)

  • Inhibition of adenosine deaminase by erythro-9-(2-hydroxy-3-nonyl)adenine (EHNA) mimics the effect of inescapable shock on escape learning in rats.

    Woodson et al (1998) Behav Neurosci 112(2) : 339-409
    Read more (PubMedID: 9588486)

3 Item(s)

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Order: HB3540
Pack PriceQty
10mg
$109
25mg
$250
Potent adenosine deaminase and PDE2 inhibitor. Supresses spontaneous hESC differentiation. Also maintains pluripotency of hESCs in the absence of exogenous cytokines.
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