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DMH-1

(HB3110)
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Product overview

Name DMH-1
Purity >98%
Description Selective ALK2 inhibitor. Promotes iPSC neurogenesis.
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (2) Reviews References (3) Frequently bought together
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Biological Data

Biological description Selective ALK2 inhibitor (IC50 = 108 nM). Blocks BMP signaling. Also promotes human induced pluripotent stem cell (iPSC ) neurogenesis when used in combination with SB 431542. Shows antitumor activity.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in DMSO (20mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name 4-[6-[4-(1-Methylethoxy)phenyl]pyra zolo[1,5-a]pyrimidin-3-yl]-quinoline
Molecular Weight 380.44
Chemical structure DMH-1 | [1206711-16-1] Chemical Structure
Molecular Formula C24H20N4O
CAS Number 1206711-16-1
PubChem identifier 50997747
SMILES CC(C)OC(C=C3)=CC=C3C(C=N2)=CN1C2=C(C4=CC=NC5=C4C=CC=C5)C=N1
InChiKey JMIFGARJSWXZSH-UHFFFAOYSA-N

References for DMH-1

References are publications that support the biological activity of the product

  • DMH1, a small molecule inhibitor of BMP type i receptors, suppresses growth and invasion of lung cancer.

    Hao et al (2014) PLoS One 9(6) : e90748
    Read more (PubMedID: 24603907)

  • DMH1, a highly selective small molecule BMP inhibitor promotes neurogenesis of hiPSCs: comparison of PAX6 and SOX1 expression during neural induction.

    Neely et al (2012) ACS Chem Neurosci 3(6) : 482-91
    Read more (PubMedID: 22860217)

  • DMH1, a novel BMP small molecule inhibitor, increases cardiomyocyte progenitors and promotes cardiac differentiation in mouse embryonic stem cells.

    Ao et al (2012) PLoS One 7(7) : e41627
    Read more (PubMedID: 22848549)

3 Item(s)

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Order: HB3110
Pack PriceQty
10mg
$208
Selective ALK2 inhibitor. Promotes iPSC neurogenesis.
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