Product overview

Name DMH-1
Purity >98%
Description Selective ALK2 inhibitor. Promotes iPSC neurogenesis.
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Biological Data

Biological description Selective ALK2 inhibitor (IC50 = 108 nM). Blocks BMP signaling. Also promotes human induced pluripotent stem cell (iPSC ) neurogenesis when used in combination with SB 431542. Shows antitumor activity.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in DMSO (20mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Purity >98%
Chemical name 4-[6-[4-(1-Methylethoxy)phenyl]pyra zolo[1,5-a]pyrimidin-3-yl]-quinoline
Molecular Weight 380.44
Chemical structure DMH-1 |  [1206711-16-1] Chemical Structure
Molecular Formula C24H20N4O
CAS Number 1206711-16-1
PubChem identifier 50997747
SMILES CC(C)OC(C=C3)=CC=C3C(C=N2)=CN1C2=C(C4=CC=NC5=C4C=CC=C5)C=N1
InChiKey JMIFGARJSWXZSH-UHFFFAOYSA-N

References for DMH-1

References are publications that support the biological activity of the product
  • DMH1, a small molecule inhibitor of BMP type i receptors, suppresses growth and invasion of lung cancer.

    Hao et al (2014) PLoS One 9(6) : e90748
  • DMH1, a highly selective small molecule BMP inhibitor promotes neurogenesis of hiPSCs: comparison of PAX6 and SOX1 expression during neural induction.

    Neely et al (2012) ACS Chem Neurosci 3(6) : 482-91
  • DMH1, a novel BMP small molecule inhibitor, increases cardiomyocyte progenitors and promotes cardiac differentiation in mouse embryonic stem cells.

    Ao et al (2012) PLoS One 7(7) : e41627

3 Item(s)