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Dorsomorphin dihydrochloride

(HB2800)
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Product overview

Name Dorsomorphin dihydrochloride
Alternative names Compound C | BML-275
Purity >98%
Description Potent, selective AMPK inhibitor. Promotes neural hPSCs differentiation and promotes cardiomyocyte differentiation in mESCs.
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (2) Reviews References (3) Frequently bought together
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Biological Data

Biological description Potent, selective and reversible AMPK inhibitor (Ki = 109 nM). Inhibits AICAR and metformin induced AMPK activation. Additionally shows activity at ALK2, ALK3 and ALK6. Also promotes cardiomyocyte differentiation in mouse embroynic stem cells (mESCs).

Solubility & Handling

Storage instructions Room temperature (desiccate)
Solubility overview Soluble in water (100mM), and in DMSO (20mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name 6-[4-[2-(1-Piperidinyl)ethoxy]pheny l]-3-(4-pyridinyl)-pyrazolo[1,5-a]pyrimidine dihydrochloride
Molecular Weight 472.41
Chemical structure Dorsomorphin dihydrochloride | Compound C, BML-275 [1219168-18-9] Chemical Structure
Molecular Formula C24H25N5O.2HCl
CAS Number 1219168-18-9
PubChem identifier 49761481
SMILES C1CCN(CC1)CCOC2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC=C5)N=C3.Cl.Cl
Source Synthetic
InChi InChI=1S/C24H25N5O.2ClH/c1-2-12-28(13-3-1)14-15-30-22-6-4-19(5-7-22)21-16-26-24-23(17-27-29(24)18-21)20-8-10-25-11-9-20;;/h4-11,16-18H,1-3,12-15H2;2*1H
InChiKey RJDVIJJQKMGPMV-UHFFFAOYSA-N
MDL number MFCD11112197
Appearance Yellow solid

References for Dorsomorphin dihydrochloride

References are publications that support the biological activity of the product

  • Compound C induces protective autophagy in cancer cells through AMPK inhibition-independent blockade of Akt/mTOR pathway.

    Vucicevic et al (2011) Autophagy 7(1) : 40-50
    Read more (PubMedID: 20980833)

  • Role of AMP-activated protein kinase in mechanism of metformin action.

    Zhou et al (2001) J Clin Invest 108(8) : 1167-74
    Read more (PubMedID: 11602624)

  • Dorsomorphin, a selective small molecule inhibitor of BMP signaling, promotes cardiomyogenesis in embryonic stem cells.

    Hao et al (18682835) PLoS One 3(8) : e2904

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Order: HB2800
Pack PriceQty
10mg
$200
50mg
$795
Potent, selective AMPK inhibitor. Promotes neural hPSCs differentiation and promotes cardiomyocyte differentiation in mESCs.
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