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Dexamethasone (water-soluble)

(HB6020)
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Product overview

Name Dexamethasone (water-soluble)
Purity >98%
Description

Synthetic glucocorticoid with potent anti-inflammatory actions. Induces hMSC differentiation. Apoptosis inducer. Water soluble and suitable for cell culture. 

Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (2) Reviews (1) References (3) Frequently bought together
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Biological Data

Biological description

Synthetic glucocorticoid which shows potent anti-inflammatory and immunospressant effects.

Induces differentiation of mesenchymal stem cells (hMSCs) into adipogenic, chondrogenic and osteogenic lineages.

Commonly used with ascorbic acid and β-Gly for osteogenic differentiation of stem cells.


This is a water soluble compound composed of a dexamethasone – Cyclodextrin complex (Approx. 65 mg dexamethasone per gm. Balance 2-hydroxypropyl-β-cyclodextrin).

Recently investigated as part of COVID-19 compound repurposing.

Apoptosis inducer.

Dexamethasone free base also available.

 

Solubility & Handling

Storage instructions -20°C (protect from light)
Solubility overview Soluble in water (100 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name (11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methyl-pregna-1,4-diene-3,20-dione
Chemical structure Dexamethasone water soluble [50-02-2] Chemical Structure
Molecular Formula C22H29FO5.xC36H60O30
CAS Number 50-02-2
PubChem identifier 71308592
SMILES CC1CC2C3CCC4=CC(=O)C=CC4(C3C(CC2(C1C(=O)CO)C)O)C.C(C1C2C(C(C(O1)OC3C(OC(C(C3O)O)OC4C(OC(C(C4O)O)OC5C(OC(C(C5O)O)OC6C(OC(C(C6O)O)OC7C(OC(C(C7O)O)OC8C(OC(O2)C(C8O)O)CO)CO)CO)CO)CO)CO)O)O)O
InChi InChI=1S/C42H70O35.C22H30O4/c43-1-8-29-15(50)22(57)36(64-8)72-30-9(2-44)66-38(24(59)17(30)52)74-32-11(4-46)68-40(26(61)19(32)54)76-34-13(6-48)70-42(28(63)21(34)56)77-35-14(7-49)69-41(27(62)20(35)55)75-33-12(5-47)67-39(25(60)18(33)53)73-31-10(3-45)65-37(71
InChiKey XEJNDGTUKUMQNG-ARJMFYCQSA-N
MDL number MFCD00064136
Appearance White to off-white solid
Formulation Approximately 65 mg dexamethasone per gm. Balance 2-hydroxypropyl-β-cyclodextrin.

References for Dexamethasone (water-soluble)

References are publications that support the biological activity of the product

  • Dexamethasone alleviates tumor-associated brain damage and angiogenesis.

    Fan Z et al (2014) PLoS One 9(4) : e93264.
    Read more (PubMedID: 24714627)

  • Short bouts of mechanical loading are as effective as dexamethasone at inducing matrix production by human bone marrow mesenchymal stem cell.

    Sittichokechaiwut A et al (2010) Eur Cell Mater 20 : 45-57.
    Read more (PubMedID: 20648425)

  • Glucocorticoid receptor antagonism by cyproterone acetate and RU486.

    Honer C et al (2003) Mol Pharmacol 63(5) : 1012-20.
    Read more (PubMedID: 12695529)

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Order: HB6020
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100mg
$106

Synthetic glucocorticoid with potent anti-inflammatory actions. Induces hMSC differentiation. Apoptosis inducer. Water soluble and suitable for cell culture. 

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