Product overview
| Name | Dexamethasone |
| Description | Anti-inflammatory synthetic glucocorticoid. Induces hMSC differentiation. |
| Alternative names | Dex |
| Purity | >98% |
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Biological Data
| Biological description | Synthetic glucocorticoid. Differentiates mesenchymal stem cells (MSCs) into adipogenic, chondrogenic and osteogenic lineages. Commonly used with ascorbic acid and β-Gly for osteogenic differentiation of stem cells. Also shows potent anti-inflammatory and immunospressant effects. Active in vivo. Recently investigated as part of COVID-19 compound repurposing. Water soluble dexamethasone also available. |
Solubility & Handling
| Storage instructions | -20°C (protect from light) |
| Solubility overview | Soluble in DSMO (100mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | (11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methyl-pregna-1,4-diene-3,20-dione |
| Molecular Weight | 392.47 |
| Chemical structure | ![Dexamethasone [50-02-2] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb2521.png "Dexamethasone [50-02-2]") |
| Molecular Formula | C22H29FO5 |
| CAS Number | 50-02-2 |
| PubChem identifier | 5743 |
| SMILES | C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)CO)O)C)O)F)C |
| InChi | InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1 |
| InChiKey | UREBDLICKHMUKA-CXSFZGCWSA-N |
| MDL number | MFCD00064136 |
References for Dexamethasone
References are publications that support the biological activity of the product
-
Dexamethasone alleviates tumor-associated brain damage and angiogenesis.
Fan Z et al (2014) PLoS One 9(4) : e93264. -
Short bouts of mechanical loading are as effective as dexamethasone at inducing matrix production by human bone marrow mesenchymal stem cell.
Sittichokechaiwut A et al (2010) Eur Cell Mater 20 : 45-57. -
Glucocorticoid receptor antagonism by cyproterone acetate and RU486.
Honer C et al (2003) Mol Pharmacol 63(5) : 1012-20.
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