Product overview

Name Dexamethasone
Alternative names Dex
Purity >98%

Anti-inflammatory synthetic glucocorticoid. Induces hMSC differentiation. Apoptosis inducer.

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Dexamethasone product vial image | Hello Bio

Biological Data

Biological description

Synthetic glucocorticoid. Differentiates mesenchymal stem cells (MSCs) into adipogenic, chondrogenic and osteogenic lineages.

Commonly used with ascorbic acid and β-Gly for osteogenic differentiation of stem cells.

Also shows potent anti-inflammatory and immunospressant effects. Active in vivo.

Recently investigated as part of COVID-19 compound repurposing.

Apoptosis inducer.

Water soluble dexamethasone also available.

Solubility & Handling

Storage instructions -20°C (protect from light)
Solubility overview Soluble in DSMO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >98%
Chemical name (11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methyl-pregna-1,4-diene-3,20-dione
Molecular Weight 392.47
Chemical structure Dexamethasone [50-02-2] Chemical Structure
Molecular Formula C22H29FO5
CAS Number 50-02-2
PubChem identifier 5743
SMILES C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)CO)O)C)O)F)C
InChi InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1
MDL number MFCD00064136

References for Dexamethasone

References are publications that support the biological activity of the product
  • Dexamethasone alleviates tumor-associated brain damage and angiogenesis.

    Fan Z et al (2014) PLoS One 9(4) : e93264.
  • Short bouts of mechanical loading are as effective as dexamethasone at inducing matrix production by human bone marrow mesenchymal stem cell.

    Sittichokechaiwut A et al (2010) Eur Cell Mater 20 : 45-57.
  • Glucocorticoid receptor antagonism by cyproterone acetate and RU486.

    Honer C et al (2003) Mol Pharmacol 63(5) : 1012-20.

3 Item(s)

These publications cite the use of Dexamethasone purchased from Hello Bio:
  • Chronic intermittent ethanol exposure disrupts stress-related tripartite communication to impact affect-related behavioral selection in male rats.

    Munier JJ et al (2023) Neurobiology of stress 24 : 100539
    PubMedID: 37131490

1 Item