Product overview

Name Dexamethasone
Description Anti-inflammatory synthetic glucocorticoid. Induces hMSC differentiation.
Alternative names Dex
Purity >98%
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Dexamethasone product vial image | Hello Bio

Biological Data

Biological description

Synthetic glucocorticoid. Differentiates mesenchymal stem cells (MSCs) into adipogenic, chondrogenic and osteogenic lineages.

Commonly used with ascorbic acid and β-Gly for osteogenic differentiation of stem cells.

Also shows potent anti-inflammatory and immunospressant effects. Active in vivo.

Recently investigated as part of COVID-19 compound repurposing.

Water soluble dexamethasone also available.

Solubility & Handling

Storage instructions -20°C (protect from light)
Solubility overview Soluble in DSMO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Chemical name (11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methyl-pregna-1,4-diene-3,20-dione
Molecular Weight 392.47
Chemical structure Dexamethasone [50-02-2] Chemical Structure
Molecular Formula C22H29FO5
CAS Number 50-02-2
PubChem identifier 5743
SMILES C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)CO)O)C)O)F)C
InChi InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1
InChiKey UREBDLICKHMUKA-CXSFZGCWSA-N
MDL number MFCD00064136

References for Dexamethasone

References are publications that support the biological activity of the product
  • Dexamethasone alleviates tumor-associated brain damage and angiogenesis.

    Fan Z et al (2014) PLoS One 9(4) : e93264.
  • Short bouts of mechanical loading are as effective as dexamethasone at inducing matrix production by human bone marrow mesenchymal stem cell.

    Sittichokechaiwut A et al (2010) Eur Cell Mater 20 : 45-57.
  • Glucocorticoid receptor antagonism by cyproterone acetate and RU486.

    Honer C et al (2003) Mol Pharmacol 63(5) : 1012-20.