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3-Deazaneplanocin A hydrochloride

(HB1416)
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Product overview

Name 3-Deazaneplanocin A hydrochloride
Alternative names DZNep
Purity >98%
Description Histone methyltransferase inhibitor. Enhances Oct4 expression in chemically-induced pluripotent stem cells.
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (2) Reviews References (3)
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Biological Data

Biological description Histone methyltransferase inhibitor. Inhibits S-adenosylhomocysteine hydrolase (SAH) and EZH2 protein expression. Also enhances Oct4 expression in chemically-induced pluripotent stem cells. Shows anti-cancer and antiviral actions.

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in water (10mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name (1S,2R,5R)-5-(4-Amino-1H-imidazo[4, 5-c]pyridin-1-yl)-3-(hydroxymethyl)-3-cyclopentene -1,2-diol hydrochloride
Molecular Weight 298.73
Chemical structure 3-Deazaneplanocin A hydrochloride [120964-45-6] Chemical Structure
Molecular Formula C12H14N4O3.HCl
CAS Number 120964-45-6
PubChem identifier 14563109
SMILES OCC([C@@H](O)[C@H]3O)=C[C@H]3N2C=NC1=C(N)N=CC=C12.Cl
InChiKey UNSKMHKAFPRFTI-FDKLLANESA-N

References for 3-Deazaneplanocin A hydrochloride

References are publications that support the biological activity of the product

  • 3-Deazaneplanocin A (DZNep), an inhibitor of the histone methyltransferase EZH2, induces apoptosis and reduces cell migration in chondrosarcoma cells.

    Girard N et al (2014) PLoS One 9(5) : e98176.
    Read more (PubMedID: 24852755)

  • Inhibition of histone methyltransferase EZH2 depletes leukemia stem cell of mixed lineage leukemia fusion leukemia through upregulation of p16.

    Ueda K et al (2014) Cancer Sci 105(5) : 512-9.
    Read more (PubMedID: 24612037)

  • Synthesis of 3-deazaneplanocin A, a powerful inhibitor of S-adenosylhomocysteine hydrolase with potent and selective in vitro and in vivo antiviral activities.

    Tseng CK et al (1989) J Med Chem 32(7) : 1442-6.
    Read more (PubMedID: 2544721)

3 Item(s)

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Order: HB1416
Pack PriceQty
500μg
$118
1mg
$173
5mg
$777
Histone methyltransferase inhibitor. Enhances Oct4 expression in chemically-induced pluripotent stem cells.
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