My Cart
My account
Menu
Main Menu

Lopinavir

(HB7108)
Be the first to add a publication

Certificate of Analysis

Latest Certificate of Analysis

Download the latest CoA for this product:

Download CoA

Download Batch-Specific CoA

To download the CoA for a batch, enter the batch ID below:

Technical documents: CoA SDS Datasheet
Be the first to review this product
Add to Wish List

Product overview

Name Lopinavir
Alternative names ABT-378
Purity >98%
Description Potent and selective HIV-1 protease inhibitor
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3)
Write Your Own Review
You're reviewing:Lopinavir
Rate this item:

Biological Data

Biological description

Potent and selective HIV-1 protease inhibitor (EC50 = 6.5 nM, against HIV cultured in peripheral blood mononuclear cells.

More potent at inhibiting HIV-1 than ritonavir in vitro but shows poor bioavailability in vivo.

Shows antiviral effect against SARS-CoV, MERS-CoV, and hCoV-229E in vitro, (mean EC50 ranged from 6.6 to 17.1µM).

Inhibits SARS-CoV-2 replication in vitro in Vero E6 cells (EC50 = < 100µM).

Also acts as a potent ER stress inducer.

Solubility & Handling

Solubility overview Soluble in DMSO (100 mM), and in ethanol (100 mM)
Storage instructions -20°C
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

Molarity

=
x
x
More Info

Dilution

x
=
x
More Info

Chemical Data

Purity >98%
Chemical name (2S)-N-[(2S,4S,5S)-5-[2-(2,6-dimethylphenoxy)acetamido]-4-hydroxy-1,6-diphenylhexan-2-yl]-3-methyl-2-(2-oxo-1,3-diazinan-1-yl)butanamide
Molecular Weight 628.8
Chemical structure Lopinavir [192725-17-0] Chemical Structure
Molecular Formula C37H48N4O5
CAS Number 192725-17-0
PubChem identifier 92727
SMILES O=C(N[C@@H](Cc1ccccc1)[C@@H](O)C[C@@H](NC(=O)[C@@H](N2C(=O)NCCC2)C(C)C)Cc3ccccc3)COc4c(cccc4C)C
InChi InChI=1S/C37H48N4O5/c1-25(2)34(41-20-12-19-38-37(41)45)36(44)39-30(21-28-15-7-5-8-16-28)23-32(42)31(22-29-17-9-6-10-18-29)40-33(43)24-46-35-26(3)13-11-14-27(35)4/h5-11,13-18,25,30-32,34,42H,12,19-24H2,1-4H3,(H,38,45)(H,39,44)(H,40,43)/t30-,31-,32-,34-/m0/
InChiKey KJHKTHWMRKYKJE-SUGCFTRWSA-N

References for Lopinavir

References are publications that support the biological activity of the product

  • Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitro

    Choy et al (2020) Antiviral Res. 178 : 104786
    Read more (PubMedID: 32251767)

  • ABT-378, a highly potent inhibitor of the human immunodeficiency virus protease

    Sham et al (1998) Antimicrob Agents Chemother 42(12) : 3218-24
    Read more (PubMedID: 9835517)

  • In vitro selection and characterization of human immunodeficiency virus type 1 variants with increased resistance to ABT-378, a novel protease inhibitor

    Carrillo et al (1998) J Virol. 72(9) : 7532-41
    Read more (PubMedID: 9696850)

3 Item(s)

Related Products
Grouped product items
Order: HB7108
Pack PriceQty
10mg
$25
50mg
$58
250mg
$197
Potent and selective HIV-1 protease inhibitor
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

Contact Us

Call 609-683-7500
Fax 609-228-4994

customercare-usa@hellobio.com

Related Products

Remdesivir
Code:
HB9521
Pack:
1mg, 10mg, 50mg
Price:
$47, $107, $433
Adenosine triphosphate analog with broad-spectrum antiviral activity
Emetine dihydrochloride
Code:
HB7389
Pack:
10mg, 50mg
Price:
$39, $143
Protein synthesis inhibitor
Homoharringtonine
Code:
HB4660
Pack:
10mg
Price:
$174
Protein synthesis inhibitor