Product overview

Name Lopinavir
Alternative names ABT-378
Purity >98%
Description Potent and selective HIV-1 protease inhibitor
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Biological Data

Biological description

Potent and selective HIV-1 protease inhibitor (EC50 = 6.5 nM, against HIV cultured in peripheral blood mononuclear cells.

More potent at inhibiting HIV-1 than ritonavir in vitro but shows poor bioavailability in vivo.

Shows antiviral effect against SARS-CoV, MERS-CoV, and hCoV-229E in vitro, (mean EC50 ranged from 6.6 to 17.1µM).

Inhibits SARS-CoV-2 replication in vitro in Vero E6 cells (EC50 = < 100µM).

Also acts as a potent ER stress inducer.

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in DMSO (100 mM), and in ethanol (100 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

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Dilution

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Chemical Data

Purity >98%
Chemical name (2S)-N-[(2S,4S,5S)-5-[2-(2,6-dimethylphenoxy)acetamido]-4-hydroxy-1,6-diphenylhexan-2-yl]-3-methyl-2-(2-oxo-1,3-diazinan-1-yl)butanamide
Molecular Weight 628.8
Chemical structure Lopinavir [192725-17-0] Chemical Structure
Molecular Formula C37H48N4O5
CAS Number 192725-17-0
PubChem identifier 92727
SMILES O=C(N[C@@H](Cc1ccccc1)[C@@H](O)C[C@@H](NC(=O)[C@@H](N2C(=O)NCCC2)C(C)C)Cc3ccccc3)COc4c(cccc4C)C
InChi InChI=1S/C37H48N4O5/c1-25(2)34(41-20-12-19-38-37(41)45)36(44)39-30(21-28-15-7-5-8-16-28)23-32(42)31(22-29-17-9-6-10-18-29)40-33(43)24-46-35-26(3)13-11-14-27(35)4/h5-11,13-18,25,30-32,34,42H,12,19-24H2,1-4H3,(H,38,45)(H,39,44)(H,40,43)/t30-,31-,32-,34-/m0/
InChiKey KJHKTHWMRKYKJE-SUGCFTRWSA-N

References for Lopinavir

References are publications that support the biological activity of the product
  • Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitro

    Choy et al (2020) Antiviral Res. 178 : 104786
  • ABT-378, a highly potent inhibitor of the human immunodeficiency virus protease

    Sham et al (1998) Antimicrob Agents Chemother 42(12) : 3218-24
  • In vitro selection and characterization of human immunodeficiency virus type 1 variants with increased resistance to ABT-378, a novel protease inhibitor

    Carrillo et al (1998) J Virol. 72(9) : 7532-41

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