Product overview
| Name | Monensin sodium salt |
| Alternative names | Monensin A, NSC 343257, MONA, MonH, Monensic acid |
| Purity | >98% |
| Description | Protein transport inhibitor. Commonly used in cytokine staining. |
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Biological Data
| Biological description | Monensin is an ionophore and protein transport inhibitor which facilitates the transmembrane exchange of sodium ions for protons. Monensin disrupts the trans-Golgi transport of proteins by interacting with Golgi membrane Na+ + /H+ transport.It also neutralizes acidic intracellular compartments and disrupts the Golgi apparatus structure and slows down and reduces the process of endocytosis.
Monensin is commonly used for intracellular staining of cytokines for flow cytometry by inducing an accumulation of cytokines in the golgi complex. Monensin also shows antibiotic action and induces apoptosis.
Additionally shows inhibitor activity towards some Coronaviruses (CoVs) (e.g. (MERS-CoV)). |
Solubility & Handling
| Storage instructions | -20°C |
| Solubility overview | Soluble in ethanol (100mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use |
Chemical Data
| Purity | >98% |
| Chemical name | 4-[2-[5-Ethyl-5-[5-[6-hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]- 3-methyloxolan-2-yl]oxolan-2-yl]- 9-hydroxy-2,8-dimethyl-1,6-dioxaspiro[4.5]dec-7-yl]-3-methoxy-2-methylpentanoic acid sodium salt |
| Molecular Weight | 692.86 |
| Chemical structure | ![Monensin sodium salt [22373-78-0] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb4882_1.png "Monensin sodium salt [22373-78-0]") |
| Molecular Formula | C36H61NaO11 |
| CAS Number | 22373-78-0 |
| PubChem identifier | 23667299 |
| SMILES | C[C@@H]([C@@H](OC)[C@@H](C(O[Na])=O)C)[C@]1([H])[C@H](C)[C@@H](O)C[C@]2(CC[C@]([C@]3([H])O[C@@]([C@@]4([H])[C@@H](C)C[C@@]([C@]5([H])[C@@H](C)C[C@@H](C)[C@@](CO)(O)O5)([H])O4)(CC)CC3)(C)O2)O1 |
| InChi | OC[C@]1(O)O[C@@H]([C@@H](C)C[C@H]1C)[C@H]2C[C@H](C)[C@@H](O2)[C@]3(CC)CC[C@@H](O3)[C@]5(C)CC[C@]4(C[C@H](O)C[C@](C)(O4)[C@@H](C)[C@@H](OC)C(C)C(=O)O)O5 |
| InChiKey | XOIQMTLWECTKJL-FBZUZRIGSA-M |
| MDL number | MFCD00077826 |
Technical guides
Understanding purity and quality - a guide for life scientistsReferences for Monensin sodium salt
References are publications that support the biological activity of the product
-
High-Throughput Screening and Identification of Potent Broad-Spectrum Inhibitors of Coronaviruses
Shen et al (2019) J Virol. : 93(12) -
Structure and antimicrobial properties of monensin A and its derivatives: summary of the achievements.
Aowicki and Huczyński (2013) Biomed Res Int. 2013 : 742149 -
Evaluation of monensin and brefeldin A for flow cytometric determination of interleukin-1 beta, interleukin-6, and tumor necrosis factor-alpha in monocytes.
Schuerwegh et al (2001) Cytometry 46(3) : 172-6 -
Monensin-induced redistribution of enzymes and products from Golgi stacks to swollen vesicles in plant cells.
Zhang et al (1996) Eur J Cell Biol. 71(4) : 332-40 -
Detection of intracellular cytokines by flow cytometry.
Jung et al (1993) J Immunol Methods. 159(1-2) : 197-207
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