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Monensin sodium salt

(HB4882)
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Product overview

Name Monensin sodium salt
Alternative names Monensin A, NSC 343257, MONA, MonH, Monensic acid
Purity >98%
Description Protein transport inhibitor. Commonly used in cytokine staining.
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (6) Frequently bought together
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Biological Data

Biological description

Monensin is an ionophore and protein transport inhibitor which facilitates the transmembrane exchange of sodium ions for protons.

Monensin disrupts the trans-Golgi transport of proteins by interacting with Golgi membrane Na+ + /H+ transport.It also neutralizes acidic intracellular compartments and disrupts the Golgi apparatus structure and slows down and reduces the process of endocytosis.


Uses

Monensin is commonly used for intracellular staining of cytokines for flow cytometry by inducing an accumulation of cytokines in the golgi complex. Monensin also shows antibiotic action and induces apoptosis.


Brefeldin A (BFA) also available.

Additionally shows inhibitor activity towards some Coronaviruses (CoVs) (e.g. (MERS-CoV)).

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in ethanol (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name 4-[2-[5-Ethyl-5-[5-[6-hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]- 3-methyloxolan-2-yl]oxolan-2-yl]- 9-hydroxy-2,8-dimethyl-1,6-dioxaspiro[4.5]dec-7-yl]-3-methoxy-2-methylpentanoic acid sodium salt
Molecular Weight 692.86
Chemical structure Monensin sodium salt [22373-78-0] Chemical Structure
Molecular Formula C36H61NaO11
CAS Number 22373-78-0
PubChem identifier 23667299
SMILES C[C@@H]([C@@H](OC)[C@@H](C(O[Na])=O)C)[C@]1([H])[C@H](C)[C@@H](O)C[C@]2(CC[C@]([C@]3([H])O[C@@]([C@@]4([H])[C@@H](C)C[C@@]([C@]5([H])[C@@H](C)C[C@@H](C)[C@@](CO)(O)O5)([H])O4)(CC)CC3)(C)O2)O1
InChi OC[C@]1(O)O[C@@H]([C@@H](C)C[C@H]1C)[C@H]2C[C@H](C)[C@@H](O2)[C@]3(CC)CC[C@@H](O3)[C@]5(C)CC[C@]4(C[C@H](O)C[C@](C)(O4)[C@@H](C)[C@@H](OC)C(C)C(=O)O)O5
InChiKey XOIQMTLWECTKJL-FBZUZRIGSA-M
MDL number MFCD00077826

References for Monensin sodium salt

References are publications that support the biological activity of the product

  • High-Throughput Screening and Identification of Potent Broad-Spectrum Inhibitors of Coronaviruses

    Shen et al (2019) J Virol. : 93(12)
    Read more (PubMedID: 30918074)

  • Structure and antimicrobial properties of monensin A and its derivatives: summary of the achievements.

    Aowicki and Huczyński (2013) Biomed Res Int. 2013 : 742149
    Read more (PubMedID: 23509771)

  • Evaluation of monensin and brefeldin A for flow cytometric determination of interleukin-1 beta, interleukin-6, and tumor necrosis factor-alpha in monocytes.

    Schuerwegh et al (2001) Cytometry 46(3) : 172-6
    Read more (PubMedID: 11449408)

  • Monensin-induced redistribution of enzymes and products from Golgi stacks to swollen vesicles in plant cells.

    Zhang et al (1996) Eur J Cell Biol. 71(4) : 332-40
    Read more (PubMedID: 8980903)

  • Detection of intracellular cytokines by flow cytometry.

    Jung et al (1993) J Immunol Methods. 159(1-2) : 197-207
    Read more (PubMedID: 8445253)

Items 1 to 5 of 6 total

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Order: HB4882
Pack PriceQty
500mg
$41
1g
$78
Protein transport inhibitor. Commonly used in cytokine staining.
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Hazardous: $35

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