Product overview

Name Ivermectin (IVM)
Alternative names IVM
Purity >95%
Description α7 nicotinic acetylcholine receptor positive allosteric modulator. Activates GluCI/GlyCI chemogenetic channels. Shows antiviral activity.
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Biological Data

Biological description

Ivermectin (IVM) is an anthelmintic and positive allosteric modulator of α7 nicotinic acetylcholine receptors. It also shows activity at purinergic P2X4 receptors.

Ivermectin modulates glutamate- and GABA-activated chloride channels and potentiates glycine-gated currents at low concentrations (30 nM).

Shows antimicrobial, anticancer and antiviral activities. Recently investigated as part of COVID-19 compound repurposing.

Use in chemogenetics

Ivermectin selectively activates the chemogenetic glutamate-gated chloride (GluCl) and glycine-gated chloride (GlyCl) channels which silence neuronal activity.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in DMSO (50 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use



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Chemical Data

Purity >95%
Chemical name 22,23-Dihydroavermectin B1
Molecular Weight 875.1
Chemical structure Ivermectin (IVM) [70288-86-7] Chemical Structure
Molecular Formula C48H74O14
CAS Number 70288-86-7
PubChem identifier 6321424
SMILES CC[C@H](C)[C@@H]1[C@H](CC[C@@]2(O1)C[C@@H]3C[C@H](O2)C/C=C(/[C@H]([C@H](/C=C/C=C/4\CO[C@H]5[C@@]4([C@@H](C=C([C@H]5O)C)C(=O)O3)O)C)O[C@H]6C[C@@H]([C@H]([C@@H](O6)C)O[C@H]7C[C@@H]([C@H]([C@@H](O7)C)O)OC)OC)\C)C
InChi InChI=1S/C48H74O14/c1-11-25(2)43-28(5)17-18-47(62-43)23-34-20-33(61-47)16-15-27(4)42(26(3)13-12-14-32-24-55-45-40(49)29(6)19-35(46(51)58-34)48(32,45)52)59-39-22-37(54-10)44(31(8)57-39)60-38-21-36(53-9)41(50)30(7)56-38/h12-15,19,25-26,28,30-31,33-45,49-50,
MDL number MFCD00869511
Appearance White solid

References for Ivermectin (IVM)

References are publications that support the biological activity of the product
  • An engineered glutamate-gated chloride (GluCl) channel for sensitive, consistent neuronal silencing by ivermectin.

    Frazier et al (23720773) J Biol Chem 288(29) : 21029-42
  • Ivermectin: potential candidate for the treatment of Covid 19

    Singh et al (2020) Braz J Infect Dis. : S1413-8670
  • A Chemogenetic Receptor That Enhances the Magnitude and Frequency of Glycinergic Inhibitory Postsynaptic Currents without Inducing a Tonic Chloride Flux.

    Islam et al (2017) ACS Chem Neurosci 8(3) : 460-467
  • Ivermectin-Activated, Cation-Permeable Glycine Receptors for the Chemogenetic Control of Neuronal Excitation.

    Islam et al (2016) ACS Chem Neurosci 7(12) : 1647-1657
  • Ivermectin: a positive allosteric effector of the alpha7 neuronal nicotinic acetylcholine receptor.

    Krause et al (1998) Mol Pharmacol 53(2) : 283-94

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