Product overview

Name Ivermectin (IVM)
Description α7 nicotinic acetylcholine receptor positive allosteric modulator. Activates GluCI/GlyCI chemogenetic channels. Shows antiviral activity.
Biological description

Ivermectin (IVM) is an anthelmintic and positive allosteric modulator of α7 nicotinic acetylcholine receptors. It also shows activity at purinergic P2X4 receptors.


Ivermectin modulates glutamate- and GABA-activated chloride channels and potentiates glycine-gated currents at low concentrations (30 nM).

Shows antimicrobial, anticancer and antiviral activities. Recently investigated as part of COVID-19 compound repurposing.


Use in chemogenetics

Ivermectin selectively activates the chemogenetic glutamate-gated chloride (GluCl) and glycine-gated chloride (GlyCl) channels which silence neuronal activity.

Alternative names IVM
Purity >95%
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Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in DMSO (50 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

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Chemical Data

Chemical name 22,23-Dihydroavermectin B1
Molecular Weight 875.1
Chemical structure Product image
Molecular Formula C48H74O14
CAS Number 70288-86-7
PubChem identifier 6321424
SMILES CC[C@H](C)[C@@H]1[C@H](CC[C@@]2(O1)C[C@@H]3C[C@H](O2)C/C=C(/[C@H]([C@H](/C=C/C=C/4\CO[C@H]5[C@@]4([C@@H](C=C([C@H]5O)C)C(=O)O3)O)C)O[C@H]6C[C@@H]([C@H]([C@@H](O6)C)O[C@H]7C[C@@H]([C@H]([C@@H](O7)C)O)OC)OC)\C)C
InChi InChI=1S/C48H74O14/c1-11-25(2)43-28(5)17-18-47(62-43)23-34-20-33(61-47)16-15-27(4)42(26(3)13-12-14-32-24-55-45-40(49)29(6)19-35(46(51)58-34)48(32,45)52)59-39-22-37(54-10)44(31(8)57-39)60-38-21-36(53-9)41(50)30(7)56-38/h12-15,19,25-26,28,30-31,33-45,49-50,
InChiKey AZSNMRSAGSSBNP-XPNPUAGNSA-N
MDL number MFCD00869511
Appearance White solid

References for Ivermectin (IVM)

References are publications that support the biological activity of the product
  • Ivermectin: a positive allosteric effector of the alpha7 neuronal nicotinic acetylcholine receptor.

    Krause et al (1998) Mol Pharmacol 53(2) : 283-94
  • An engineered glutamate-gated chloride (GluCl) channel for sensitive, consistent neuronal silencing by ivermectin.

    Frazier et al (23720773) J Biol Chem 288(29) : 21029-42
  • Ivermectin-Activated, Cation-Permeable Glycine Receptors for the Chemogenetic Control of Neuronal Excitation.

    Islam et al (2016) ACS Chem Neurosci 7(12) : 1647-1657
  • A Chemogenetic Receptor That Enhances the Magnitude and Frequency of Glycinergic Inhibitory Postsynaptic Currents without Inducing a Tonic Chloride Flux.

    Islam et al (2017) ACS Chem Neurosci 8(3) : 460-467
  • Ivermectin: potential candidate for the treatment of Covid 19

    Singh et al (2020) Braz J Infect Dis. : S1413-8670