Ivermectin (IVM)

Name: Ivermectin (IVM)
Brand: Hello Bio
SKU: HB1958
Price: 55 USD
Availability: InStock

(HB1958)

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Technical documents: SDS CoA Datasheet

Product overview

Name

Ivermectin (IVM)

Alternative names

IVM

Purity

>95%

Description

α7 nicotinic acetylcholine receptor positive allosteric modulator. Activates GluCI/GlyCI chemogenetic channels. Shows antiviral activity.

Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) References (5) Frequently bought together

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Biological Data

Biological description

Ivermectin (IVM) is an anthelmintic and positive allosteric modulator of α7 nicotinic acetylcholine receptors. It also shows activity at purinergic P2X₄ receptors.

Ivermectin modulates glutamate- and GABA-activated chloride channels and potentiates glycine-gated currents at low concentrations (30 nM).

Shows antimicrobial, anticancer and antiviral activities. Recently investigated as part of COVID-19 compound repurposing.

Use in chemogenetics

Ivermectin selectively activates the chemogenetic glutamate-gated chloride (GluCl) and glycine-gated chloride (GlyCl) channels which silence neuronal activity.

Solubility & Handling

Solubility overview

Soluble in DMSO (50 mM)

Storage instructions

+4°C

Storage of solutions

Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.

Shipping Conditions

Stable for ambient temperature shipping. Follow storage instructions on receipt.

Important

This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

Molarity

More Info

Dilution

More Info

Chemical Data

Purity

>95%

Chemical name

22,23-Dihydroavermectin B1

Molecular Weight

875.1

Chemical structure

Molecular Formula

C₄₈H₇₄O₁₄

CAS Number

70288-86-7

PubChem identifier

6321424

SMILES

CC[C@H](C)[C@@H]1[C@H](CC[C@@]2(O1)C[C@@H]3C[C@H](O2)C/C=C(/[C@H]([C@H](/C=C/C=C/4\CO[C@H]5[C@@]4([C@@H](C=C([C@H]5O)C)C(=O)O3)O)C)O[C@H]6C[C@@H]([C@H]([C@@H](O6)C)O[C@H]7C[C@@H]([C@H]([C@@H](O7)C)O)OC)OC)\C)C

InChi

InChI=1S/C48H74O14/c1-11-25(2)43-28(5)17-18-47(62-43)23-34-20-33(61-47)16-15-27(4)42(26(3)13-12-14-32-24-55-45-40(49)29(6)19-35(46(51)58-34)48(32,45)52)59-39-22-37(54-10)44(31(8)57-39)60-38-21-36(53-9)41(50)30(7)56-38/h12-15,19,25-26,28,30-31,33-45,49-50,

InChiKey

AZSNMRSAGSSBNP-XPNPUAGNSA-N

MDL number

MFCD00869511

Appearance

White solid

Technical guides

Understanding purity and quality - a guide for life scientists (159.4 KB)

References for Ivermectin (IVM)

References are publications that support the biological activity of the product

An engineered glutamate-gated chloride (GluCl) channel for sensitive, consistent neuronal silencing by ivermectin.
Frazier et al (23720773) J Biol Chem 288(29) : 21029-42
Ivermectin: potential candidate for the treatment of Covid 19
Singh et al (2020) Braz J Infect Dis. : S1413-8670
Read more (PubMedID: 32615072)
A Chemogenetic Receptor That Enhances the Magnitude and Frequency of Glycinergic Inhibitory Postsynaptic Currents without Inducing a Tonic Chloride Flux.
Islam et al (2017) ACS Chem Neurosci 8(3) : 460-467
Read more (PubMedID: 27958714 )
Ivermectin-Activated, Cation-Permeable Glycine Receptors for the Chemogenetic Control of Neuronal Excitation.
Islam et al (2016) ACS Chem Neurosci 7(12) : 1647-1657
Read more (PubMedID: 27611437)
Ivermectin: a positive allosteric effector of the alpha7 neuronal nicotinic acetylcholine receptor.
Krause et al (1998) Mol Pharmacol 53(2) : 283-94
Read more (PubMedID: 9463487)

α7 nicotinic acetylcholine receptor positive allosteric modulator. Activates GluCI/GlyCI chemogenetic channels. Shows antiviral activity.

Order: HB1958
Pack	Price	Qty
100mg	$55

Ivermectin (IVM)

Product overview

Biological Data

Solubility & Handling

Calculators

Molarity

Dilution

Chemical Data

Technical guides

References for Ivermectin (IVM)

An engineered glutamate-gated chloride (GluCl) channel for sensitive, consistent neuronal silencing by ivermectin.

Ivermectin: potential candidate for the treatment of Covid 19

A Chemogenetic Receptor That Enhances the Magnitude and Frequency of Glycinergic Inhibitory Postsynaptic Currents without Inducing a Tonic Chloride Flux.

Ivermectin-Activated, Cation-Permeable Glycine Receptors for the Chemogenetic Control of Neuronal Excitation.

Ivermectin: a positive allosteric effector of the alpha7 neuronal nicotinic acetylcholine receptor.

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Tell us about your publication!

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Ivermectin (IVM)

Product overview

Biological Data

Solubility & Handling

Calculators

Molarity

Dilution

Chemical Data

Technical guides

References for Ivermectin (IVM)

An engineered glutamate-gated chloride (GluCl) channel for sensitive, consistent neuronal silencing by ivermectin.

Ivermectin: potential candidate for the treatment of Covid 19

A Chemogenetic Receptor That Enhances the Magnitude and Frequency of Glycinergic Inhibitory Postsynaptic Currents without Inducing a Tonic Chloride Flux.

Ivermectin-Activated, Cation-Permeable Glycine Receptors for the Chemogenetic Control of Neuronal Excitation.

Ivermectin: a positive allosteric effector of the alpha7 neuronal nicotinic acetylcholine receptor.

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