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Images Ebselen product vial image | Hello Bio
Ebselen product vial image | Hello Bio Biological Data Biological description Broad enzyme inhibitor which inhibits PKC, NADPH, NADPH oxidase, NO synthases, 5-lipoxygenase and cyclooxygenase.
It also mimics glutathione peroxidase.
It shows neuroprotective, anti-cancer, antioxidant and anti-inflammatory actions.
It also shows antiviral activity and inhibits the SARS-CoV-2 Mpro protease (IC50 = 0.67 µM).
Selectively inhibits Gq protein signaling and enhances differentiation of brown adipocytes.
Solubility & Handling Storage instructions Room temperature
Solubility overview Soluble in DMSO (100 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name 2-Phenyl-1,2-benzisoselenazol-3(2H)-one
Chemical structure
Molecular Formula C13 H9 NOSe
SMILES C1=CC=C(C=C1)N2C(=O)C3=CC=CC=C3[Se]2
InChi InChI=1S/C13H9NOSe/c15-13-11-8-4-5-9-12(11)16-14(13)10-6-2-1-3-7-10/h1-9H
InChiKey DYEFUKCXAQOFHX-UHFFFAOYSA-N
References for Ebselen References are publications that support the biological activity of the product
Structure of M pro from SARS-CoV-2 and discovery of its inhibitors Yang et al (2020) Nature (7811) : 289-293 Induction of apoptosis in human multiple myeloma cell lines by ebselen via enhancing the endogenous reactive oxygen species production. Zhang L et al (2014) Biomed Res Int 2014 : 696107 Ebselen pretreatment attenuates ischemia/reperfusion injury and prevents hyperglycemia by improving hepatic insulin signaling and β-cell survival in gerbils. Park S et al (2014) Free Radic Res 48(8) : 864-74. Molecular actions of ebselen--an antiinflammatory antioxidant. Schewe T (1995) Gen Pharmacol 26(6) : 1153-69. Studies on the anti-inflammatory activity of ebselen. Ebselen interferes with granulocyte oxidative burst by dual inhibition of NADPH oxidase and protein kinase C? Cotgreave IA et al (1989) Biochem Pharmacol 38(4) : 649-56.
Publications
These publications cite the use of Ebselen purchased from Hello Bio:
Glutaminase activity in GLS1 Het mouse brain compared to putative pharmacological inhibition by ebselen using ex vivo MRS Kosten L et al (2019) Neurochem Int 129 : 104508 Preclinical molecular imaging to elucidate the role of the glutamatergic system in mood disorders Kosten et al (2019) University of Antwerp : Thesis
Broad enzyme inhibitor. Inhibits Gq protein signaling.
![Ebselen [60940-34-3] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0270.png "Ebselen [60940-34-3]")
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