Product overview

Name Ebselen
Purity >98%

Broad enzyme inhibitor. Inhibits Gq protein signaling.

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Ebselen product vial image | Hello Bio

Biological Data

Biological description

Broad enzyme inhibitor which inhibits PKC, NADPH, NADPH oxidase, NO synthases, 5-lipoxygenase and cyclooxygenase.

It also mimics glutathione peroxidase.

It shows neuroprotective, anti-cancer, antioxidant and anti-inflammatory actions.

It also shows antiviral activity and inhibits the SARS-CoV-2 Mpro protease (IC50 = 0.67 µM).

Selectively inhibits Gq protein signaling and enhances differentiation of brown adipocytes.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in DMSO (100 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >98%
Chemical name 2-Phenyl-1,2-benzisoselenazol-3(2H)-one
Molecular Weight 274.2
Chemical structure Ebselen  [60940-34-3] Chemical Structure
Molecular Formula C13H9NOSe
CAS Number 60940-34-3
PubChem identifier 3194
InChi InChI=1S/C13H9NOSe/c15-13-11-8-4-5-9-12(11)16-14(13)10-6-2-1-3-7-10/h1-9H
MDL number MFCD00210937

References for Ebselen

References are publications that support the biological activity of the product
  • Structure of M pro from SARS-CoV-2 and discovery of its inhibitors

    Yang et al (2020) Nature (7811) : 289-293
  • Induction of apoptosis in human multiple myeloma cell lines by ebselen via enhancing the endogenous reactive oxygen species production.

    Zhang L et al (2014) Biomed Res Int 2014 : 696107
  • Ebselen pretreatment attenuates ischemia/reperfusion injury and prevents hyperglycemia by improving hepatic insulin signaling and β-cell survival in gerbils.

    Park S et al (2014) Free Radic Res 48(8) : 864-74.
  • Molecular actions of ebselen--an antiinflammatory antioxidant.

    Schewe T (1995) Gen Pharmacol 26(6) : 1153-69.
  • Studies on the anti-inflammatory activity of ebselen. Ebselen interferes with granulocyte oxidative burst by dual inhibition of NADPH oxidase and protein kinase C?

    Cotgreave IA et al (1989) Biochem Pharmacol 38(4) : 649-56.

5 Item(s)

These publications cite the use of Ebselen purchased from Hello Bio:
  • Glutaminase activity in GLS1 Het mouse brain compared to putative pharmacological inhibition by ebselen using ex vivo MRS

    Kosten L et al (2019) Neurochem Int 129 : 104508
    PubMedID: 31326460
  • Preclinical molecular imaging to elucidate the role of the glutamatergic system in mood disorders

    Kosten et al (2019) University of Antwerp : Thesis

2 Item(s)