Broad enzyme inhibitor which inhibits PKC, NADPH, NADPH oxidase, NO synthases, 5-lipoxygenase and cyclooxygenase.
It also mimics glutathione peroxidase.
It shows neuroprotective, anti-cancer, antioxidant and anti-inflammatory actions.
It also shows antiviral activity and inhibits the SARS-CoV-2 Mpro protease (IC50 = 0.67 µM).
Selectively inhibits Gq protein signaling and enhances differentiation of brown adipocytes.
Solubility & Handling
Solubility overview
Soluble in DMSO (100 mM)
Storage instructions
Room temperature
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Ebselen pretreatment attenuates ischemia/reperfusion injury and prevents hyperglycemia by improving hepatic insulin signaling and β-cell survival in gerbils.
Park S et al (2014) Free Radic Res 48(8) : 864-74.
Studies on the anti-inflammatory activity of ebselen. Ebselen interferes with granulocyte oxidative burst by dual inhibition of NADPH oxidase and protein kinase C?
Cotgreave IA et al (1989) Biochem Pharmacol 38(4) : 649-56.
![Ebselen [60940-34-3] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb0270.png "Ebselen [60940-34-3]")
Understanding purity and quality - a guide for life scientists