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Biological Data Biological description Highly potent and selective vacuolar-type proton translocating ATPase (V-ATPase) inhibitor (IC50 = 50 pM for chromaffin granule membranes).
Displays neuroprotective, pro-apoptotic and antibiotic properties.
Inhibits autophagy by targeting lysosomes. Increases LC3-II by inhibiting its degradation.
Recently investigated as part of COVID-19 compound repurposing.
Solubility & Handling Storage instructions -20°C
Solubility overview Soluble in DMSO (100 mM)
Handling Avoid freeze-thaw cycles. Aliquots of stock solutions should only be thawed once, immediately before use
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name (3Z,5E,7R,8S,9S,11E,13E,15S,16R)-8-Hydroxy-16-[(1S,2R,3S)-2-hydroxy-1-methyl-3-[(2R,4R,5S,6R)-tetrahydro-2,4-dihydroxy-5-methyl-6-(1-methylethyl)-2H-pyran-2-yl]butyl]-3,15-dimethoxy-5,7,9,11-tetramethyloxacyclohexadeca-3,5,11,13-tetraen-2-one
Molecular Formula C35 H58 O9
PubChem identifier 6436223
SMILES C[C@H]1C/C(=C/C=C/[C@@H]([C@H](OC(=O)/C(=C/C(=C/[C@H]([C@H]1O)C)/C)/OC)[C@@H](C)[C@H]([C@H](C)[C@]2(C[C@H]([C@@H]([C@H](O2)C(C)C)C)O)O)O)OC)/C
InChiKey XDHNQDDQEHDUTM-JQWOJBOSSA-N
Appearance White to off-white
References for Bafilomycin A1 References are publications that support the biological activity of the product
Bafilomycin A1 inhibits chloroquine-induced death of cerebellar granule neurons. Shacka JJ et al (2006) Mol Pharmacol 69(4) : 1125-36. Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells. Yamamoto A et al (1998) Cell Struct Funct 23(1) : 33-42. Bafilomycins: a class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells. Bowman EJ et al (1988) Proc Natl Acad Sci U S A 85(21) : 7972-6.
Publications
These publications cite the use of Bafilomycin A1 purchased from Hello Bio:
Different glutamate sources and endogenous co-agonists activate extrasynaptic NMDA receptors on amacrine cells of the rod pathway microcircuit Beltran-Matas et al (2021) Eur J Neurosci. : 54(2)
Highly potent, selective V-ATPase inhibitor. Autophagy inhibitor.
Understanding purity and quality - a guide for life scientists
