Highly potent and selective vacuolar-type proton translocating ATPase (V-ATPase) inhibitor (IC50 = 50 pM for chromaffin granule membranes).
Displays neuroprotective, pro-apoptotic and antibiotic properties.
Inhibits autophagy by targeting lysosomes. Increases LC3-II by inhibiting its degradation.
Recently investigated as part of COVID-19 compound repurposing.
Solubility & Handling
Solubility overview
Soluble in DMSO (100 mM)
Storage instructions
-20°C
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Handling
Avoid freeze-thaw cycles. Aliquots of stock solutions should only be thawed once, immediately before use
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells.
Yamamoto A et al (1998) Cell Struct Funct 23(1) : 33-42.
Understanding purity and quality - a guide for life scientists
