Bafilomycin A1

(HB1125)
Technical documents: SDS CoA Datasheet
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Product overview

Name Bafilomycin A1
Purity >98%
Description Highly potent, selective V-ATPase inhibitor. Autophagy inhibitor.
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Biological Data

Biological description

Highly potent and selective vacuolar-type proton translocating ATPase (V-ATPase) inhibitor (IC50 = 50 pM for chromaffin granule membranes).

Displays neuroprotective, pro-apoptotic and antibiotic properties.

Inhibits autophagy by targeting lysosomes. Increases LC3-II by inhibiting its degradation.

Recently investigated as part of COVID-19 compound repurposing.

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in DMSO (100 mM)
Handling Avoid freeze-thaw cycles. Aliquots of stock solutions should only be thawed once, immediately before use
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Purity >98%
Chemical name (3Z,5E,7R,8S,9S,11E,13E,15S,16R)-8-Hydroxy-16-[(1S,2R,3S)-2-hydroxy-1-methyl-3-[(2R,4R,5S,6R)-tetrahydro-2,4-dihydroxy-5-methyl-6-(1-methylethyl)-2H-pyran-2-yl]butyl]-3,15-dimethoxy-5,7,9,11-tetramethyloxacyclohexadeca-3,5,11,13-tetraen-2-one
Molecular Weight 622.84
Molecular Formula C35H58O9
CAS Number 88899-55-2
PubChem identifier 6436223
SMILES C[C@H]1C/C(=C/C=C/[C@@H]([C@H](OC(=O)/C(=C/C(=C/[C@H]([C@H]1O)C)/C)/OC)[C@@H](C)[C@H]([C@H](C)[C@]2(C[C@H]([C@@H]([C@H](O2)C(C)C)C)O)O)O)OC)/C
InChiKey XDHNQDDQEHDUTM-JQWOJBOSSA-N
MDL number MFCD06795130
Appearance White to off-white

References for Bafilomycin A1

References are publications that support the biological activity of the product
  • Bafilomycin A1 inhibits chloroquine-induced death of cerebellar granule neurons.

    Shacka JJ et al (2006) Mol Pharmacol 69(4) : 1125-36.
  • Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells.

    Yamamoto A et al (1998) Cell Struct Funct 23(1) : 33-42.
  • Bafilomycins: a class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells.

    Bowman EJ et al (1988) Proc Natl Acad Sci U S A 85(21) : 7972-6.

3 Item(s)

Publications
These publications cite the use of Bafilomycin A1 purchased from Hello Bio:
  • Different glutamate sources and endogenous co-agonists activate extrasynaptic NMDA receptors on amacrine cells of the rod pathway microcircuit

    Beltran-Matas et al (2021) Eur J Neurosci. : 54(2)
    PubMedID: 34048091

1 Item