|Description|| Inosine monophosphatase dehydrogenase inhibitor |
|Biological description|| |
Antibiotic which is a potent, reversible inosine monophosphatase dehydrogenase inhibitor. It is 5-fold more potent at type II compared to type I isoforms.
It is also an iNOS inhibitor and additionally inhibits RNA and DNA synthesis. It shows immunosuppressive, antiviral, antifungal and antitumor properties andinduces apoptosis and necrosis.
Recently investigated as part of COVID-19 compound repurposing.
Solubility & Handling
|Storage instructions|| Room temperature |
|Solubility overview|| Soluble in DMSO (100 mM) |
|Important|| This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
|Chemical name|| 6-(1,3-Dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4-hexenoic acid |
|Chemical structure|| |
|Molecular Formula|| C17H20O6 |
|PubChem identifier|| 446541 |
|SMILES|| COC1=C(C)C2=C(C(=O)OC2)C(O)=C1C\C=C(/C)CCC(O)=O |
|InChi|| InChI=1S/C17H20O6/c1-9(5-7-13(18)19)4-6-11-15(20)14-12(8-23-17(14)21)10(2)16(11)22-3/h4,20H,5-8H2,1-3H3,(H,18,19)/b9-4+ |
|InChiKey|| HPNSFSBZBAHARI-RUDMXATFSA-N |
|Appearance|| White to off-white solid |
References for Mycophenolic acid
References are publications that support the biological activity of the product