Product overview
| Name | Dynasore |
| Description | Cell-permeable, non-competitive dynamin inhibitor |
| Purity | >99% |
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Biological Data
| Biological description | Overview Cell-permeable, non-competitive dynamin inhibitor which inhibits the GTPase activity of dynamin 1, dynamin 2 and Drp1 (mitochondrial dynamin). It does not inhibit other small GTPases. Uses and applications Fast acting and reversible by washout. Dynasore inhibits clathrin- and dynamin-dependent endocytosis in cells including neurons. Dynasore has additionally been shown to inhibit proliferation, induce apoptosis of lung cancer cells and to enhance the inhibitory effects of cisplatin. |
Solubility & Handling
| Storage instructions | -20°C |
| Solubility overview | Soluble in DMSO (100 mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Purity | >99% |
| Chemical name | 3-Hydroxynaphthalene-2-carboxylic acid (3,4-dihydroxybenzylidene)hydrazide |
| Molecular Weight | 322.32 |
| Chemical structure | ![Dynasore [304448-55-3] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb1245.png "Dynasore [304448-55-3]") |
| Molecular Formula | C18H14N2O4 |
| CAS Number | 304448-55-3 |
| PubChem identifier | 135533054 |
| SMILES | C1=CC=C2C=C(C(=CC2=C1)C(=O)N/N=C/C3=CC(=C(C=C3)O)O)O |
| InChi | InChI=1S/C18H14N2O4/c21-15-6-5-11(7-17(15)23)10-19-20-18(24)14-8-12-3-1-2-4-13(12)9-16(14)22/h1-10,21-23H,(H,20,24)/b19-10+ |
| InChiKey | SYNDQCRDGGCQRZ-VXLYETTFSA-N |
| MDL number | MFCD11045288 |
| Appearance | Off-white solid |
References for Dynasore
References are publications that support the biological activity of the product
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Dynasore protects mitochondria and improves cardiac lusitropy in Langendorff perfused mouse heart.
Gao D et al (2013) PLoS One 8(4) : e60967. -
Dynasore, a dynamin inhibitor, suppresses lamellipodia formation and cancer cell invasion by destabilizing actin filaments.
Yamada H et al (2009) Biochem Biophys Res Commun 390(4) : 1142-8. -
Dynasore inhibits removal of wild-type and DeltaF508 cystic fibrosis transmembrane conductance regulator (CFTR) from the plasma membrane.
Young A et al (2009) Biochem J 421(3) : 377-85. -
Dynasore, a cell-permeable inhibitor of dynamin.
Macia E et al (2006) Dev Cell 10(6) : 839-50.
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