Product overview

Name Dynasore
Purity >99%
Description Cell-permeable, non-competitive dynamin inhibitor
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Biological Data

Biological description


Cell-permeable, non-competitive dynamin inhibitor which inhibits the GTPase activity of dynamin 1, dynamin 2 and Drp1 (mitochondrial dynamin). It does not inhibit other small GTPases.

Uses and applications

Fast acting and reversible by washout.

Dynasore inhibits clathrin- and dynamin-dependent endocytosis in cells including neurons.

Dynasore has additionally been shown to inhibit proliferation, induce apoptosis of lung cancer cells and to enhance the inhibitory effects of cisplatin.

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in DMSO (100 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >99%
Chemical name 3-Hydroxynaphthalene-2-carboxylic acid (3,4-dihydroxybenzylidene)hydrazide
Molecular Weight 322.32
Chemical structure Dynasore  [304448-55-3] Chemical Structure
Molecular Formula C18H14N2O4
CAS Number 304448-55-3
PubChem identifier 135533054
InChi InChI=1S/C18H14N2O4/c21-15-6-5-11(7-17(15)23)10-19-20-18(24)14-8-12-3-1-2-4-13(12)9-16(14)22/h1-10,21-23H,(H,20,24)/b19-10+
MDL number MFCD11045288
Appearance Off-white solid

References for Dynasore

References are publications that support the biological activity of the product
  • Dynasore protects mitochondria and improves cardiac lusitropy in Langendorff perfused mouse heart.

    Gao D et al (2013) PLoS One 8(4) : e60967.
  • Dynasore, a dynamin inhibitor, suppresses lamellipodia formation and cancer cell invasion by destabilizing actin filaments.

    Yamada H et al (2009) Biochem Biophys Res Commun 390(4) : 1142-8.
  • Dynasore inhibits removal of wild-type and DeltaF508 cystic fibrosis transmembrane conductance regulator (CFTR) from the plasma membrane.

    Young A et al (2009) Biochem J 421(3) : 377-85.
  • Dynasore, a cell-permeable inhibitor of dynamin.

    Macia E et al (2006) Dev Cell 10(6) : 839-50.

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