Cell-permeable, non-competitive dynamin inhibitor which inhibits the GTPase activity of dynamin 1, dynamin 2 and Drp1 (mitochondrial dynamin). It does not inhibit other small GTPases.
Uses and applications
Fast acting and reversible by washout.
Dynasore inhibits clathrin- and dynamin-dependent endocytosis in cells including neurons.
Dynasore has additionally been shown to inhibit proliferation, induce apoptosis of lung cancer cells and to enhance the inhibitory effects of cisplatin.
Solubility & Handling
Storage instructions
-20°C
Solubility overview
Soluble in DMSO (100 mM)
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Y-27632 is a selective ROCK inhibitor. Frequently used 3D growth matrix component and for production of organoids. Also used when inducing neurons from fibroblasts. Manufactured to a high degree of optical purity.
![Dynasore [304448-55-3] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb1245.png "Dynasore [304448-55-3]")
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