Cell-permeable, non-competitive dynamin inhibitor which inhibits the GTPase activity of dynamin 1, dynamin 2 and Drp1 (mitochondrial dynamin). It does not inhibit other small GTPases.
Uses and applications
Fast acting and reversible by washout.
Dynasore inhibits clathrin- and dynamin-dependent endocytosis in cells including neurons.
Dynasore has additionally been shown to inhibit proliferation, induce apoptosis of lung cancer cells and to enhance the inhibitory effects of cisplatin.
Solubility & Handling
Solubility overview
Soluble in DMSO (100 mM)
Storage instructions
-20°C
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Y-27632 is a selective ROCK inhibitor. Frequently used 3D growth matrix component and for production of organoids. Also used when inducing neurons from fibroblasts. Manufactured to a high degree of optical purity.
![Dynasore [304448-55-3] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb1245.png "Dynasore [304448-55-3]")
Understanding purity and quality - a guide for life scientists
