Dynasore

Overview

Cell-permeable, non-competitive dynamin inhibitor which inhibits the GTPase activity of dynamin 1, dynamin 2 and Drp1 (mitochondrial dynamin). It does not inhibit other small GTPases.

Uses and applications

Fast acting and reversible by washout.

Dynasore inhibits clathrin- and dynamin-dependent endocytosis in cells including neurons.

Dynasore has additionally been shown to inhibit proliferation, induce apoptosis of lung cancer cells and to enhance the inhibitory effects of cisplatin.