Product overview

Name Digoxin
Purity >98%
Description Na+ / K+ ATPase α subunit inhibitor. Antiviral.
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Biological Data

Biological description

Na+ / K+ ATPase α subunit inhibitor (IC50 = 2.69 µM) which increases regulator of G protein signaling 2 (RGS2) protein levels (EC50 = 83 nM). Exhibits little or no effect on RGS4. Also potent HIV-1 replication inhibitor and exhibits anti-MERS-CoV activity in Vero cells in vitro.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >98%
Chemical name 4-[(3S,5R,8R,9S,10S,12R,13S,14S)-3-[(2S,4S,5R,6R)-5-[(2S,4S,5R,6R)-5-[(2S,4S,5R,6R)-4,5-dihydroxy-6-methyl-oxan-2-yl]oxy-4-hydroxy-6-methyl-oxan-2-yl]oxy-4-hydroxy-6-methyl-oxan-2-yl]oxy-12,14-dihydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-5H-furan-2-one
Molecular Weight 780.949
Chemical structure Digoxin  [20830-75-5] Chemical Structure
Molecular Formula C41H64O14
CAS Number 20830-75-5
PubChem identifier 2724385
SMILES O=C\1OC/C(=C/1)[C@H]2CC[C@@]8(O)[C@]2(C)[C@H](O)C[C@H]7[C@H]8CC[C@H]6[C@]7(C)CC[C@H](O[C@@H]5O[C@H](C)[C@@H](O[C@@H]4O[C@@H]([C@@H](O[C@@H]3O[C@@H]([C@@H](O)[C@@H](O)C3)C)[C@@H](O)C4)C)[C@@H](O)C5)C6
InChi InChI=1S/C41H64O14/c1-19-36(47)28(42)15-34(50-19)54-38-21(3)52-35(17-30(38)44)55-37-20(2)51-33(16-29(37)43)53-24-8-10-39(4)23(13-24)6-7-26-27(39)14-31(45)40(5)25(9-11-41(26,40)48)22-12-32(46)49-18-22/h12,19-21,23-31,33-38,42-45,47-48H,6-11,13-18H2,1-5H3/t
MDL number MFCD00003674

References for Digoxin

References are publications that support the biological activity of the product
  • Drug repurposing for new, efficient, broad spectrum antivirals

    Pacheco et al (2019) VIrus Res. 264 : 22-31
  • Digoxin suppresses HIV-1 replication by altering viral RNA processing.

    Wong RW et al (2013) PLoS Pathog 9(3) : e1003241.
  • Cardiotonic steroids stabilize regulator of G protein signaling 2 protein levels.

    Sjögren B et al (2012) Mol Pharmacol 82(3) : 500-9.
  • Digoxin in the management of cardiovascular disorders.

    Gheorghiade M et al (2004) Circulation 109(24) : 2959-64.
  • Inhibition of Na,K-ATPase by oleandrin and oleandrigenin, and their detection by digoxin immunoassays.

    Jortani SA et al (1996) Clin Chem 42(10) : 1654-8.

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