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Group I (mGlu5, mGlu1)
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Group I metabotropic glutamate receptors (mGlu1, mGlu5) are coupled with phospholipase C (PLC) via Gq proteins; activation causes increased levels of IP3 and diacylglycerol, with intracellullar Ca2+ release and protein kinase C (PKC) activation. Group I receptors are predominantly located post synaptically. Researchers can save 50% on group I metabotropic glutamate receptor agonists, antagonists, positive allosteric modulators (PAMs) and negative allosteric modulators (NAMs) from Hello Bio - they are up to half the price of other suppliers.
Loperamide hydrochloride (HB0385)
Description:Potent, selective µ-opioid receptor agonist
Purity:>99%
LY-367385 hydrochloride (HB5153)
Description:Potent, highly selective mGlu1a antagonist. Water soluble.
LY 272015 hydrochloride (HB1750)
Description:High affinity, selective 5-HT2B receptor antagonist
Purity:>98%