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Biological Data Biological description Mitochondrial hexokinase inhibitor; inhibits glycolysis. Blocks CFTR channel currents (Kd = 58 µM). Shows antispermatogenic and antitumor actions.
Solubility & Handling Solubility overview Soluble in ethanol (5mM) or DMSO (100mM)
Storage instructions Room temperature
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name 1-[(2,4-Dichlorophenyl)methyl]-1H -indazole-3-carboxylic acid
Chemical structure
Molecular Formula C15 H10 Cl2 N2 O2
SMILES OC(=O)C1=NN(CC2=C(Cl)C=C(Cl)C=C2)C2=CC=CC=C12
InChiKey WDRYRZXSPDWGEB-UHFFFAOYSA-N
References for Lonidamine References are publications that support the biological activity of the product
Lonidamine: basic science and rationale for treatment of prostatic proliferative disorders. Brawer MK (2005) Rev Urol 7 Suppl 7 : S21-6. Recent studies on lonidamine, the lead compound of the antispermatogenic indazol-carboxylic acids. Gatto MT et al (2002) Contraception 65(4) : 277-8. Mechanism of lonidamine inhibition of the CFTR chloride channel. Gong X et al (2002) Br J Pharmacol 137(6) : 928-36.
Mitochondrial hexokinase inhibitor
![Lonidamine [50264-69-2] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb0993.png "Lonidamine [50264-69-2]")
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