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Biological Data
| Biological description | Mitochondrial hexokinase inhibitor; inhibits glycolysis. Blocks CFTR channel currents (Kd = 58 µM). Shows antispermatogenic and antitumor actions. |
Solubility & Handling
| Storage instructions | Room temperature |
| Solubility overview | Soluble in ethanol (5mM) or DMSO (100mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | 1-[(2,4-Dichlorophenyl)methyl]-1H-indazole-3-carboxylic acid |
| Chemical structure | ![Lonidamine [50264-69-2] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "Lonidamine [50264-69-2]") |
| Molecular Formula | C15H10Cl2N2O2 |
| SMILES | OC(=O)C1=NN(CC2=C(Cl)C=C(Cl)C=C2)C2=CC=CC=C12 |
| InChiKey | WDRYRZXSPDWGEB-UHFFFAOYSA-N |
References for Lonidamine
References are publications that support the biological activity of the product
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Lonidamine: basic science and rationale for treatment of prostatic proliferative disorders.
Brawer MK (2005) Rev Urol 7 Suppl 7 : S21-6. -
Recent studies on lonidamine, the lead compound of the antispermatogenic indazol-carboxylic acids.
Gatto MT et al (2002) Contraception 65(4) : 277-8. -
Mechanism of lonidamine inhibition of the CFTR chloride channel.
Gong X et al (2002) Br J Pharmacol 137(6) : 928-36.
Mitochondrial hexokinase inhibitor
![Lonidamine [50264-69-2] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0993.png "Lonidamine [50264-69-2]")
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