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Lonidamine

(HB0993)
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Product overview

Name Lonidamine
Alternative names AF 1890
Purity >98%
Description Mitochondrial hexokinase inhibitor
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3) Frequently bought together
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Biological Data

Biological description Mitochondrial hexokinase inhibitor; inhibits glycolysis. Blocks CFTR channel currents (Kd = 58 µM). Shows antispermatogenic and antitumor actions.

Solubility & Handling

Solubility overview Soluble in ethanol (5mM) or DMSO (100mM)
Storage instructions Room temperature
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name 1-[(2,4-Dichlorophenyl)methyl]-1H-indazole-3-carboxylic acid
Molecular Weight 321.16
Chemical structure Lonidamine [50264-69-2] Chemical Structure
Molecular Formula C15H10Cl2N2O2
CAS Number 50264-69-2
PubChem identifier 39562
SMILES OC(=O)C1=NN(CC2=C(Cl)C=C(Cl)C=C2)C2=CC=CC=C12
InChiKey WDRYRZXSPDWGEB-UHFFFAOYSA-N

References for Lonidamine

References are publications that support the biological activity of the product

  • Lonidamine: basic science and rationale for treatment of prostatic proliferative disorders.

    Brawer MK (2005) Rev Urol 7 Suppl 7 : S21-6.
    Read more (PubMedID: 16986057)

  • Recent studies on lonidamine, the lead compound of the antispermatogenic indazol-carboxylic acids.

    Gatto MT et al (2002) Contraception 65(4) : 277-8.
    Read more (PubMedID: 12020777)

  • Mechanism of lonidamine inhibition of the CFTR chloride channel.

    Gong X et al (2002) Br J Pharmacol 137(6) : 928-36.
    Read more (PubMedID: 12411425)

3 Item(s)

Grouped product items
Order: HB0993
Pack PriceQty
50mg
$341
100mg
$538
Mitochondrial hexokinase inhibitor
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

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