Product overview

Name Lonidamine
Description Mitochondrial hexokinase inhibitor
Biological description Mitochondrial hexokinase inhibitor; inhibits glycolysis. Blocks CFTR channel currents (Kd = 58 µM). Shows antispermatogenic and antitumor actions.
Alternative names AF 1890
Purity >98%
Write Your Own Review
You're reviewing:Lonidamine
Rate this item:

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in ethanol (5mM) or DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

=
x
x
More Info

Dilution

x
=
x
More Info

Chemical Data

Chemical name 1-[(2,4-Dichlorophenyl)methyl]-1H-indazole-3-carboxylic acid
Molecular Weight 321.16
Chemical structure Product image
Molecular Formula C15H10Cl2N2O2
CAS Number 50264-69-2
PubChem identifier 39562
SMILES OC(=O)C1=NN(CC2=C(Cl)C=C(Cl)C=C2)C2=CC=CC=C12
InChiKey WDRYRZXSPDWGEB-UHFFFAOYSA-N

References for Lonidamine

References are publications that support the biological activity of the product
  • Mechanism of lonidamine inhibition of the CFTR chloride channel.

    Gong X et al (2002) Br J Pharmacol 137(6) : 928-36.
  • Lonidamine: basic science and rationale for treatment of prostatic proliferative disorders.

    Brawer MK (2005) Rev Urol 7 Suppl 7 : S21-6.
  • Recent studies on lonidamine, the lead compound of the antispermatogenic indazol-carboxylic acids.

    Gatto MT et al (2002) Contraception 65(4) : 277-8.