Product overview
| Name | Linopirdine dihydrochloride |
| Description | Kv7 channel blocker |
| Alternative names | DuP 996 |
| Purity | >98% |
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Biological Data
| Biological description | Kv7 channel blocker. Increases ACh release in the brain and blocks M currents (IC50 = 2.4 µM). Induces increased neocortical Fos protein expression in aged rats. Also agonises TRPV1 (transient receptor potential vanilloid type 1) channel. Shows excitatory actions on nociceptors and shows cognition enhancing actions. |
Solubility & Handling
| Storage instructions | Room temperature (desiccate) |
| Solubility overview | Soluble in water (100mM) and in DMSO (100 mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | 1,3-Dihydro-1-phenyl-3,3-bis(4-pyridinylmethyl)-2H-indol-2-one dihydrochloride |
| Molecular Weight | 464.39 |
| Chemical structure | ![Linopirdine dihydrochloride [113168-57-3] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb1082.png "Linopirdine dihydrochloride [113168-57-3]") |
| Molecular Formula | C26H21N3O.2HCl |
| CAS Number | 113168-57-3 |
| PubChem identifier | 14209557 |
| SMILES | C1=CC=C(C=C1)N2C3=CC=CC=C3C(C2=O)(CC4=CC=NC=C4)CC5=CC=NC=C5.Cl.Cl |
| InChi | InChI=1S/C26H21N3O.2ClH/c30-25-26(18-20-10-14-27-15-11-20,19-21-12-16-28-17-13-21)23-8-4-5-9-24(23)29(25)22-6-2-1-3-7-22;;/h1-17H,18-19H2;2*1H |
| InChiKey | ZEVVHCGTTNRYOY-UHFFFAOYSA-N |
| MDL number | MFCD00867216 |
References for Linopirdine dihydrochloride
References are publications that support the biological activity of the product
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The M-channel blocker linopirdine is an agonist of the capsaicin receptor TRPV1.
Neacsu C et al (2010) J Pharmacol Sci 114(3) : 332-40. -
The acetylcholine release enhancer linopirdine induces Fos in neocortex of aged rats.
Dent GW et al (2001) Neurobiol Aging 22(3) : 485-94. -
Selectivity of linopirdine (DuP 996), a neurotransmitter release enhancer, in blocking voltage-dependent and calcium-activated potassium currents in hippocampal neurons.
Schnee ME et al (1998) J Pharmacol Exp Ther 286(2) : 709-17.
Publications
These publications cite the use of Linopirdine dihydrochloride purchased from Hello Bio:
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The paracetamol metabolite N-acetylp-benzoquinone imine reduces excitability in first- and second-order neurons of the pain pathway through actions on KV7 channels.
Ray et al (2019) Pain. 160(4) : 954-964PubMedID: 30601242
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