Linopirdine dihydrochloride

(HB1082)
Technical documents: SDS CoA Datasheet

Product overview

Name Linopirdine dihydrochloride
Description Kv7 channel blocker
Alternative names DuP 996
Purity >98%
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Biological Data

Biological description Kv7 channel blocker. Increases ACh release in the brain and blocks M currents (IC50 = 2.4 µM). Induces increased neocortical Fos protein expression in aged rats. Also agonises TRPV1 (transient receptor potential vanilloid type 1) channel. Shows excitatory actions on nociceptors and shows cognition enhancing actions.

Solubility & Handling

Storage instructions Room temperature (desiccate)
Solubility overview Soluble in water (100mM) and in DMSO (100 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Chemical name 1,3-Dihydro-1-phenyl-3,3-bis(4-pyridinylmethyl)-2H-indol-2-one dihydrochloride
Molecular Weight 464.39
Chemical structure Linopirdine dihydrochloride  [113168-57-3] Chemical Structure
Molecular Formula C26H21N3O.2HCl
CAS Number 113168-57-3
PubChem identifier 14209557
SMILES C1=CC=C(C=C1)N2C3=CC=CC=C3C(C2=O)(CC4=CC=NC=C4)CC5=CC=NC=C5.Cl.Cl
InChi InChI=1S/C26H21N3O.2ClH/c30-25-26(18-20-10-14-27-15-11-20,19-21-12-16-28-17-13-21)23-8-4-5-9-24(23)29(25)22-6-2-1-3-7-22;;/h1-17H,18-19H2;2*1H
InChiKey ZEVVHCGTTNRYOY-UHFFFAOYSA-N
MDL number MFCD00867216

References for Linopirdine dihydrochloride

References are publications that support the biological activity of the product
  • The M-channel blocker linopirdine is an agonist of the capsaicin receptor TRPV1.

    Neacsu C et al (2010) J Pharmacol Sci 114(3) : 332-40.
  • The acetylcholine release enhancer linopirdine induces Fos in neocortex of aged rats.

    Dent GW et al (2001) Neurobiol Aging 22(3) : 485-94.
  • Selectivity of linopirdine (DuP 996), a neurotransmitter release enhancer, in blocking voltage-dependent and calcium-activated potassium currents in hippocampal neurons.

    Schnee ME et al (1998) J Pharmacol Exp Ther 286(2) : 709-17.
Publications
These publications cite the use of Linopirdine dihydrochloride purchased from Hello Bio:
  • The paracetamol metabolite N-acetylp-benzoquinone imine reduces excitability in first- and second-order neurons of the pain pathway through actions on KV7 channels.

    Ray et al (2019) Pain. 160(4) : 954-964
    PubMedID: 30601242

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