Selective, orally available I2-imidazoline receptor ligand (Ki ratio = 286 for α2 / I2 receptors). Induces morphological/biochemical changes to astroglia, reduces apoptosis and modulates oxidative stress to show neuroprotective effects. Chronic low-dose treatment of LSL60101 also reverses cognitive deficits and impaired social behaviour in 5XFAD mice to alter Alzheimer's disease markers such as glial activation and synaptic dysfunction. Both LSL60101 treatment and LSL60101 / donepezil combination treatment decreases amyloid-β40 and amyloid-β42 levels, amyloid-β plaque number and tau hyperphosphorylation to attenuate amyloid-β pathology in 5XFAD brains.
Solubility & Handling
Solubility overview
Soluble in DMSO (100 mM), and in ethanol (100 mM)
Storage instructions
+4°C
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use
![LSL60101 [150985-54-9] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb7094.png "LSL60101 [150985-54-9]")
Understanding purity and quality - a guide for life scientists
