Potent, selective and competitive mGlu1a receptor antagonist (IC50 = 8.8 μM for blockade of quis-induced phosphoinositide (PI) hydrolysis, compared with >100μM for mGluR5 mediated responses). Water soluble form of LY367385. Impairs induction and late phases of both LTP and LTD when applied before high-frequency tetanization (HFT) or low-frequency stimulation (LFS). Shows antidepressant, anticonvulsant and neuroprotective effects.
Solubility & Handling
Solubility overview
Soluble in water (100 mM)
Storage instructions
Room temperature
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Understanding purity and quality - a guide for life scientists
