Potent, selective and competitive mGlu1a receptor antagonist (IC50 = 8.8 μM for blockade of quis-induced phosphoinositide (PI) hydrolysis, compared with >100μM for mGluR5 mediated responses). Water soluble form of LY367385. Impairs induction and late phases of both LTP and LTD when applied before high-frequency tetanization (HFT) or low-frequency stimulation (LFS). Shows antidepressant, anticonvulsant and neuroprotective effects.
Solubility & Handling
Storage instructions
Room temperature
Solubility overview
Soluble in water (100 mM)
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Understanding purity and quality - a guide for life scientists
