Group I (mGlu5, mGlu1)
Group I metabotropic glutamate receptors (mGlu1, mGlu5) are coupled with phospholipase C (PLC) via Gq proteins; activation causes increased levels of IP3 and diacylglycerol, with intracellullar Ca2+ release and protein kinase C (PKC) activation. Group I receptors are predominantly located post synaptically. Researchers can save 50% on group I metabotropic glutamate receptor agonists, antagonists, positive allosteric modulators (PAMs) and negative allosteric modulators (NAMs) from Hello Bio - they are up to half the price of other suppliers.
(3S,6R)-Lateritin (HB3694)
Description:Acyl-CoA cholesterol acyltransferase (ACAT) inhibitor
Purity:>97%
LDN193189 hydrochloride (LDN) (HB5624)
Description:Potent, selective ALK2/ALK3 inhibitor which also promotes neural induction of hPSCs. May be used as a component for brain organoid production.
Purity:>98%
Leupeptin hemisulfate (HB3958)
Description:Reversible trypsin-like and cysteine proteases inhibitor
Purity:>97%
Linagliptin (HB4637)
Description:Highly potent, selective, competitive dipeptidyl-peptidase 4 inhibitor
Purity:>98%