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LY 272015 hydrochloride

(HB1750)
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Product overview

Name LY 272015 hydrochloride
Purity >98%
Description High affinity, selective 5-HT2B receptor antagonist
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3)
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Biological Data

Biological description

High affinity, selective 5-HT2B receptor antagonist with selectivity over 5-HT2A and 5-HT2C receptors (Ki values are 0.75, 21.63 and 28.7 nM at 5-HT2B, 5-HT2C and 5-HT2A receptors respectively). Active in vivo and orally active. Displays antihypertensive activity.

Solubility & Handling

Storage instructions  +4°C
Solubility overview Soluble in DMSO (100 mM), and in ethanol (10 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name 1-[(3,4-Dimethoxyphenyl)methy]-2,3,4,9-tetrahydro-6-methyl-1H-pyrido[3,4-b]indole
Molecular Weight 372.89
Chemical structure LY 272015 [172895-15-7] Chemical Structure
CAS Number 172895-15-7
PubChem identifier 9929423
SMILES CC1=CC2=C(C=C1)NC3=C2CCNC3CC4=CC(=C(C=C4)OC)OC.Cl
InChi InChI=1S/C21H24N2O2.ClH/c1-13-4-6-17-16(10-13)15-8-9-22-18(21(15)23-17)11-14-5-7-19(24-2)20(12-14)25-3;/h4-7,10,12,18,22-23H,8-9,11H2,1-3H3;1H
InChiKey BKAZOTIBKRWLQA-UHFFFAOYSA-N

References for LY 272015 hydrochloride

References are publications that support the biological activity of the product

  • Expression and function of serotonin 2A and 2B receptors in the mammalian respiratory network

    Niebert et al (2011) PLoS One 7 : e21395
    Read more (PubMedID: 21789169)

  • In vivo modulation of vagal-identified dorsal medullary neurones by activation of different 5-Hydroxytryptamine(2) receptors in rats

    Sevoz-Couche et al (2000) Br J Pharmacol. 7 : 1445-53
    Read more (PubMedID: 11090119)

  • LY272015, a potent, selective and orally active 5-HT2B receptor antagonist.

    Cohen et al (1996) J.Serotonin Res. 131 : 3

3 Item(s)

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Grouped product items
Order: HB1750
Pack PriceQty
10mg
$139
50mg
$601
High affinity, selective 5-HT2B receptor antagonist
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