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Lomeguatrib

(HB1376)
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Product overview

Name Lomeguatrib
Alternative names PaTrin-2; Patrin; O6-(4-bromothenyl)guanine; 4-BTG
Purity >98%
Description Potent MGMT inhibitor
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3)
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Biological Data

Biological description Potent O6-methylguanine-DNA methyltransferase (MGMT) inhibitor (IC50 = 9 nM). Acts as a pseudosubstrate. Enhances temozolomide anti-tumor activity. Shows anti-cancer actions.

Solubility & Handling

Solubility overview Soluble in DMSO (100mM)
Storage instructions +4°C
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name 6-[(4-Bromo-2-thienyl)methoxy]-9H-p urin-2-amine
Molecular Weight 326.17
Chemical structure Lomeguatrib [192441-08-0] Chemical Structure
Molecular Formula C10H8BrN5OS
CAS Number 192441-08-0
PubChem identifier 3025944
SMILES NC1=NC(OCC3=CC(Br)=CS3)=C2C(N=CN2)=N1
InChiKey JUJPKFNFCWJBCX-UHFFFAOYSA-N

References for Lomeguatrib

References are publications that support the biological activity of the product

  • The therapeutic potential of O6-alkylguanine DNA alkyltransferase inhibitors.

    Khan O et al (2007) Expert Opin Investig Drugs 16(10) : 1573-84.
    Read more (PubMedID: 17922622)

  • O6-(4-bromothenyl)guanine reverses temozolomide resistance in human breast tumour MCF-7 cells and xenografts.

    Clemons M et al (2005) Br J Cancer 93(10) : 1152-6.
    Read more (PubMedID: 16278661)

  • Monosaccharide-linked inhibitors of O(6)-methylguanine-DNA methyltransferase (MGMT): synthesis, molecular modeling, and structure-activity relationships.

    Reinhard J et al (2001) J Med Chem 44(24) : 4050-61.
    Read more (PubMedID: 11708909)

3 Item(s)

Grouped product items
Order: HB1376
Pack PriceQty
10mg
$201
25mg
$430
Potent MGMT inhibitor
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

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