Product overview

Name Lomeguatrib
Description Potent MGMT inhibitor
Alternative names PaTrin-2; Patrin; O6-(4-bromothenyl)guanine; 4-BTG
Purity >98%
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Biological Data

Biological description Potent O6-methylguanine-DNA methyltransferase (MGMT) inhibitor (IC50 = 9 nM). Acts as a pseudosubstrate. Enhances temozolomide anti-tumor activity. Shows anti-cancer actions.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Chemical name 6-[(4-Bromo-2-thienyl)methoxy]-9H-p urin-2-amine
Molecular Weight 326.17
Chemical structure Lomeguatrib  [192441-08-0] Chemical Structure
Molecular Formula C10H8BrN5OS
CAS Number 192441-08-0
PubChem identifier 3025944
SMILES NC1=NC(OCC3=CC(Br)=CS3)=C2C(N=CN2)=N1
InChiKey JUJPKFNFCWJBCX-UHFFFAOYSA-N

References for Lomeguatrib

References are publications that support the biological activity of the product
  • The therapeutic potential of O6-alkylguanine DNA alkyltransferase inhibitors.

    Khan O et al (2007) Expert Opin Investig Drugs 16(10) : 1573-84.
  • O6-(4-bromothenyl)guanine reverses temozolomide resistance in human breast tumour MCF-7 cells and xenografts.

    Clemons M et al (2005) Br J Cancer 93(10) : 1152-6.
  • Monosaccharide-linked inhibitors of O(6)-methylguanine-DNA methyltransferase (MGMT): synthesis, molecular modeling, and structure-activity relationships.

    Reinhard J et al (2001) J Med Chem 44(24) : 4050-61.