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Loperamide hydrochloride

(HB0385)
Publications (1)
Technical documents: SDS Datasheet
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Product overview

Name Loperamide hydrochloride
Purity >99%
Description Potent, selective µ-opioid receptor agonist
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews Publications (1) References (3) Frequently bought together
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Biological Data

Biological description Potent and selective µ-opioid receptor agonist (Ki values are 3, 48 and 1156 nM for µ, δ and κ). Blocks voltage-activated calcium channels and also NMDA receptor Ca2+ influx at higher concentrations. Shows antidiarrheal and antihyperalgesic actions.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in ethanol (50mM) or DMSO (50mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >99%
Chemical name 4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-1-piperidinebutanamidehydrochloride
Molecular Weight 513.51
Chemical structure Loperamide hydrochloride [34552-83-5] Chemical Structure
Molecular Formula C29H33ClN2O2.HCl
CAS Number 34552-83-5
PubChem identifier 71420
SMILES Cl.CN(C)C(=O)C(CCN1CCC(O)(CC1)C1=CC=C(Cl)C=C1)(C1=CC=CC=C1)C1=CC=CC=C1
InChiKey PGYPOBZJRVSMDS-UHFFFAOYSA-N

References for Loperamide hydrochloride

References are publications that support the biological activity of the product

  • Loperamide (ADL 2-1294), an opioid antihyperalgesic agent with peripheral selectivity.

    DeHaven-Hudkins DL et al (1999) J Pharmacol Exp Ther 289(1) : 494-502.
    Read more (PubMedID: 10087042)

  • Maitotoxin-elicited calcium influx in cultured cells. Effect of calcium-channel blockers.

    Daly JW et al (1995) Biochem Pharmacol 50(8) : 1187-97.
    Read more (PubMedID: 7488233)

  • Loperamide blocks high-voltage-activated calcium channels and N-methyl-D-aspartate-evoked responses in rat and mouse cultured hippocampal pyramidal neurons.

    Church J et al (1994) Mol Pharmacol 45(4) : 747-57.
    Read more (PubMedID: 8183255)

3 Item(s)

Publications
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These publications cite the use of Loperamide hydrochloride purchased from Hello Bio:

  • Mechanisms Underlying Long-Term Synaptic Zinc Plasticity at Mouse Dorsal Cochlear Nucleus Glutamatergic Synapses

    Vogler NW et al (2020) J Neurosci 40(26) : 4981-4996
    PubMedID: 32434779

1 Item

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Order: HB0385
Pack PriceQty
1g
$58
Potent, selective µ-opioid receptor agonist
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