DREADD
Designer receptors exclusively activated by designer drugs (DREADDs) are genetically engineered GPCRs that are activated by physiologically inert synthetic small molecules (designer drugs) but not their endogenous ligand. Read our DREADDs mini-review or for practical advice on using these ligands in the lab see Stability of Water-Soluble DREADD Ligands in Solution: A Technical Review and Clozapine N-Oxide (freebase) - a technical review on stability, solubility and use in the lab).
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Tranylcypromine hydrochloride (HB1412)
Description:LSD1 / MAO inhibitor. Enables reprogramming of mouse embryonic fibroblasts into iPS cells.
Purity:>98%
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Trichostatin A (HB1402)
Description:Potent HDAC inhibitor. Induces hiPSCs differentiation to cardiogenic cells and induces accelerated dedifferentiation of primordial germ cells.
Purity:>98%
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Tropisetron hydrochloride (HB2827)
Description:Potent 5-HT3 receptor antagonist. Also α7 nAChR partial agonist. Activates α7Q79G-GlyR chimeric ion channels.
Purity:>99%
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TTA-P2 (HB5851)
Description:Potent, selective, reversible T-type calcium channel blocker
Purity:>98%
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(+)-Tubocurarine chloride (HB2050)
Description:Nicotinic acetylcholine receptors (nACHR) antagonist. Neuromuscular blocker.
Purity:>98%
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