Tripolin A

(HB4112)

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Product overview

Name Tripolin A
Purity >98%
Description Non-ATP competitive Aurora A and B kinase inhibitor
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Biological Data

Biological description Non-ATP competitive Aurora A and B kinase inhibitor (IC50 = 1.5, 7 and >10 µM at Aurora A, B, EGFR, FGFR, KDR and IGF1R respectively). Reduces localization of pAurora A on spindle microtubules (MTs), affects centrosome integrity, spindle formation and length and MT dynamics in interphase.

Solubility & Handling

Storage instructions +4°C
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

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Chemical Data

Purity >98%
Chemical name (3E)-3-[(2,5-Dihydroxyphenyl)methylene]-1,3-dihydro-2H-indol-2-one
Molecular Weight 253.3
Chemical structure Tripolin A [1148118-92-6] Chemical Structure
CAS Number 1148118-92-6
InChiKey OMKSBDLWMROKNU-WQLSENKSSA-N
Appearance Yellow solid