Non-ATP competitive Aurora A and B kinase inhibitor (IC50 = 1.5, 7 and >10 µM at Aurora A, B, EGFR, FGFR, KDR and IGF1R respectively). Reduces localization of pAurora A on spindle microtubules (MTs), affects centrosome integrity, spindle formation and length and MT dynamics in interphase.
Solubility & Handling
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.