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TTA-P2

(HB5851)
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Product overview

Name TTA-P2
Purity >98%
Description Potent, selective, reversible T-type calcium channel blocker
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3)
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Biological Data

Biological description

Potent, selective, reversible T-type calcium channel blocker (IC50 = 100nM at DRG T currents) with no activity at high voltage calcium channels. Shows antinociceptive to reduces pain responses in mice. Also reverses thermal hyperalgesia in a streptozocin induced rat diabetes model.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in DMSO (50 mM), and in ethanol (50 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

Molarity

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x
More Info

Dilution

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More Info

Chemical Data

Purity >98%
Chemical name

3,5-Dichloro-N-((1-((2,2-dimethyltetrahydro-2H-pyran-4-yl) methyl)-4-fluoropiperidin-4-yl)methyl)benzamide

Molecular Weight 431.4
Chemical structure TTA-P2 [918430-49-6] Chemical Structure
Molecular Formula

C21H29Cl2FN2O2

CAS Number 918430-49-6
PubChem identifier 16005493
SMILES Clc1cc(cc(Cl)c1)C(=O)NCC1(F)CCN(CC1)CC1CC(C)(C)OCC1
InChi InChI=1S/C21H29Cl2FN2O2/c1-20(2)12-15(3-8-28-20)13-26-6-4-21(24,5-7-26)14-25-19(27)16-9-17(22)11-18(23)10-16/h9-11,15H,3-8,12-14H2,1-2H3,(H,25,27)
InChiKey DKNDOKIVCXTFHJ-UHFFFAOYSA-N
MDL number MFCD11977740
Appearance Pale brown solid

References for TTA-P2

References are publications that support the biological activity of the product

  • Inhibition of T-Type Calcium Channels With TTA-P2 Reduces Chronic Neuropathic Pain Following Spinal Cord Injury in Rats.

    Liu H et al (2023) The journal of pain 24 : 1681-1695
    Read more (PubMedID: 37169156)

  • Enhanced T-type calcium channel 3.2 activity in sensory neurons contributes to neuropathic-like pain of monosodium iodoacetate-induced knee osteoarthritis.

    Shin SM et al (2020) Molecular pain 16 : 1744806920963807
    Read more (PubMedID: 33054557)

  • TTA-P2 is a potent and selective blocker of T-type calcium channels in rat sensory neurons and a novel antinociceptive agent.

    Choe W et al (2011) Molecular pharmacology 80 : 900-10
    Read more (PubMedID: 21821734)

3 Item(s)

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Grouped product items
Order: HB5851
Pack PriceQty
5mg
$102
10mg
$183
50mg
$749
Potent, selective, reversible T-type calcium channel blocker
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

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