Product overview

Name Tunicamycin
Alternative names TUN, TM
Purity >98%
Description ER Stress inducer which induces cell death
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Biological Data

Biological description

Tunicamycin is an antibiotic which is commonly used to induce ER (endoplasmic reticulum) stress and activate the unfolded protein response (UPR) to induce cell death.

Tunicamycin inhibits the DPAGT1 enzyme to inhibit one of the first steps of glycoprotein biosynthesis in the ER which results in the accumulation of misfolded proteins to cause subsequent ER stress.

ER stress can often be induced by treating cells with tunicamycin at 2.5-5 µg/ml of tunicamycin for 5 hours.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in DMSO (50mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >98%
Chemical name Tunicamycin from Streptomyces sp.
Molecular Weight 844.95
Chemical structure Tunicamycin  [11089-65-9] Chemical Structure
Molecular Formula C39H64N4O16 (tunicamycin C, n=10)
CAS Number 11089-65-9
PubChem identifier 90488851
SMILES O=C(C=C3)NC(N3[C@@H]2O[C@@H]([C@@H](O)[C@H]2O)[C@H](O)C[C@@H]1[C@H](O)[C@H](O)[C@@H](NC(/C=C/CCCCCCCCCCC(C)C)=O)[C@H](OC4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4NC(C)=O)O1)=O
Source Streptomyces sp
MDL number MFCD00065709
Appearance Off-white solid

References for Tunicamycin

References are publications that support the biological activity of the product
  • SEC24A identified as an essential mediator of thapsigargin-induced cell death in a genome-wide CRISPR/Cas9 screen.

    Chidawanyika et al (2018) Cell Death Dis : doi: 10.1038/s41420-018-0135-5
  • Tunicamycin induced endoplasmic reticulum stress promotes apoptosis of prostate cancer cells by activating mTORC1.

    Guha et al (2017) Oncotarget 8(40) : 68191-68207
  • A novel endoplasmic reticulum stress‑induced apoptosis model using tunicamycin in primary cultured neonatal rat cardiomyocytes.

    Shen et al (2015) Mol Med Rep 12(4) : 5149-54
  • Dipeptidyl petidase-IV inhibitor (gemigliptin) inhibits tunicamycin-induced endoplasmic reticulum stress, apoptosis and inflammation in H9c2 cardiomyocytes.

    Hwang HJ et al (2014) Mol Cell Endocrinol 392(1-2) : 1-7.
  • Tunicamycin potentiates CDDP anticancer efficacy through the DPAGT1/Akt/ABCG2 pathway in mouse Xenograft models of human hepatocellular carcinoma.

    Hou H et al (2013) Mol Cancer Ther 12(12) : 2874-84.

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