Product overview

Name (+)-Tubocurarine chloride
Description Nicotinic acetylcholine receptors (nACHR) antagonist. Neuromuscular blocker.
Alternative names DTC, d-tubocurarine
Purity >98%
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Biological Data

Biological description

Tubocurarine is a competitive, non-selective nicotinic acetylcholine receptors (nACHR) antagonist which blocks neuromuscular transmission.

Tubocurarine is also a GABAA and 5-HT3 receptor antagonist.

Solubility & Handling

Storage instructions +4°C (desiccate)
Solubility overview Soluble in water (25 mM), and in DMSO (10 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

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Dilution

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Chemical Data

Chemical name (13aR,25aS)-2,3,13a,14,15,16,25,25a-Octahydro-9,19-dihydroxy-18,29-dimethoxy-1,14,14-trimethyl-13H-4,6:21,24-dietheno-8,12-metheno-1H-pyrido[3',2':14,15][1,11]dioxacycloeicosino[2,3,4-ij]isoquinolinium chloride hydrochloride pentahydrate
Molecular Weight 771.72
Chemical structure (+)-Tubocurarine [6989-98-6] Chemical Structure
Molecular Formula C37H41ClN2O6.HCl.5H2O
CAS Number 6989-98-6
PubChem identifier 23422
SMILES CN1CCC2=CC(=C3C=C2[C@@H]1CC4=CC=C(C=C4)OC5=C6[C@@H](CC7=CC(=C(C=C7)O)O3)[N+](CCC6=CC(=C5O)OC)(C)C)OC.O.O.O.O.O.Cl.[Cl-]
InChi InChI=1S/C37H40N2O6.2ClH.5H2O/c1-38-14-12-24-19-32(42-4)33-21-27(24)28(38)16-22-6-9-26(10-7-22)44-37-35-25(20-34(43-5)36(37)41)13-15-39(2,3)29(35)17-23-8-11-30(40)31(18-23)45-33;;;;;;;/h6-11,18-21,28-29H,12-17H2,1-5H3,(H-,40,41);2*1H;5*1H2/t28-,29+;;;;;;;
InChiKey WMIZITXEJNQAQK-GGDSLZADSA-N
MDL number MFCD00150157
Appearance White solid

References for (+)-Tubocurarine chloride

References are publications that support the biological activity of the product
  • Pre-and post-junctional effects of tubocurarine and other nicotinic antagonists during repetitive stimulation in the rat.

    Gibb and Marhsall (1984) J Physiol 351 : 275-97
  • The effect of (+)-tubocurarine on neuromuscular transmission during repetitive stimulation in the rat, mouse, and frog.

    Magleby et al (1981) J Physiol. 312 : 97-113
  • The actions of tubocurarine at the frog neuromuscular junction.

    Colquhoun et al (1979) J Physiol. 293 : 247-84