Tropisetron hydrochloride
(HB2827)
Product overview
| Name | Tropisetron hydrochloride |
| Description | Potent 5-HT3 receptor antagonist. Also α7 nAChR partial agonist. Activates α7Q79G-GlyR chimeric ion channels. |
| Alternative names | ICS 205930|Novaban |
| Purity | >99% |
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Biological Data
| Biological description | Potent 5-HT3 receptor antagonist. Also α7 nAChR partial agonist. It additionally activates α7Q79G-GlyR chimeric ion channels (EC50 = 38 nM). Active in vivo. Also shows anti-emetic activity. |
Solubility & Handling
| Storage instructions | Room temperature (desiccate) |
| Solubility overview | Soluble in water (100mM) and in DMSO (50mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | [(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 1H-indole-3-carboxylate;hydrochloride |
| Molecular Weight | 320.81 |
| Molecular Formula | C17H21ClN2O2 |
| CAS Number | 105826-92-4 |
| PubChem identifier | 656664 |
| SMILES | CN1[C@@H]2CC[C@H]1CC(C2)OC(=O)C3=CNC4=CC=CC=C43.Cl |
| InChi | InChI=1S/C17H20N2O2.ClH/c1-19-11-6-7-12(19)9-13(8-11)21-17(20)15-10-18-16-5-3-2-4-14(15)16;/h2-5,10-13,18H,6-9H2,1H3;1H/t11-,12+,13?; |
| InChiKey | XIEGSJAEZIGKSA-KOQCZNHOSA-N |
| MDL number | MFCD00210221 |
References for Tropisetron hydrochloride
References are publications that support the biological activity of the product
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Ultrapotent Chemogenetics for Research and Potential Clinical Applications
Magnus et al (2019) Science 364(6436) : 5282 -
Tropisetron in the Prevention of Acute Nausea and Vomiting in Patients Treated With High Dose Epirubicin
Nicolaides et al (1998) J Exp Clin Cancer Res. 17(1) : 71-5
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