Product overview

Name Tropisetron hydrochloride
Description Potent 5-HT3 receptor antagonist. Also α7 nAChR partial agonist. Activates α7Q79G-GlyR chimeric ion channels.
Alternative names ICS 205930|Novaban
Purity >99%
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Biological Data

Biological description

Potent 5-HT3 receptor antagonist. Also α7 nAChR partial agonist.

It additionally activates α7Q79G-GlyR chimeric ion channels (EC50 = 38 nM). Active in vivo.

Also shows anti-emetic activity.

Solubility & Handling

Storage instructions Room temperature (desiccate)
Solubility overview Soluble in water (100mM) and in DMSO (50mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Chemical name [(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 1H-indole-3-carboxylate;hydrochloride
Molecular Weight 320.81
Molecular Formula C17H21ClN2O2
CAS Number 105826-92-4
PubChem identifier 656664
SMILES CN1[C@@H]2CC[C@H]1CC(C2)OC(=O)C3=CNC4=CC=CC=C43.Cl
InChi InChI=1S/C17H20N2O2.ClH/c1-19-11-6-7-12(19)9-13(8-11)21-17(20)15-10-18-16-5-3-2-4-14(15)16;/h2-5,10-13,18H,6-9H2,1H3;1H/t11-,12+,13?;
InChiKey XIEGSJAEZIGKSA-KOQCZNHOSA-N
MDL number MFCD00210221

References for Tropisetron hydrochloride

References are publications that support the biological activity of the product
  • Ultrapotent Chemogenetics for Research and Potential Clinical Applications

    Magnus et al (2019) Science 364(6436) : 5282
  • Tropisetron in the Prevention of Acute Nausea and Vomiting in Patients Treated With High Dose Epirubicin

    Nicolaides et al (1998) J Exp Clin Cancer Res. 17(1) : 71-5