The store will not work correctly in the case when cookies are disabled.
Biological Data
| Biological description | Selective histone deacetylase 6 (HDAC6) inhibitor. Selective for HDAC6 over HDAC3, 8, 1, 5, 10, 11, 9, 2, 7 and 4 (IC50 values are 4 nM and 1.27, 1.27, 1.4, 3.35, 3.71, 3.79, 4.31, 6.27, 9.7 and 17.3 µM respectively). Induces tubulin acetylation. Shows anti-cancer, anti-proliferative and apoptotic actions. |
Solubility & Handling
| Storage instructions | -20°C |
| Solubility overview | Soluble in DMSO (10mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | N-[4-[(2R,4R,6S)-4-[[(4,5-Diphenyl- 2-oxazolyl)thio]methyl]-6-[4-(hydroxymethyl)phenyl ]-1,3-dioxan-2-yl]phenyl]-N'-hydroxyoctanediamide |
| Chemical structure | ![Tubacin [1350555-93-9] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "Tubacin [1350555-93-9]") |
| Molecular Formula | C41H43N3O7S |
| PubChem identifier | 6675804 |
| SMILES | OCC(C=C4)=CC=[C@@]4[C@@H]1C[C@H](CSC2=NC(C6=CC=CC=C6)=C(C5=CC=CC=C5)O2)O[C@H]([C@]3=CC=C(NC(CCCCCCC(NO)=O)=O)C=C3)O1 |
| InChiKey | BHUZLJOUHMBZQY-YXQOSMAKSA-N |
References for Tubacin
References are publications that support the biological activity of the product
-
Tubacin suppresses proliferation and induces apoptosis of acute lymphoblastic leukemia cells.
Aldana-Masangkay GI et al (2011) Leuk Lymphoma 52(8) : 1544-55. -
Rational design and simple chemistry yield a superior, neuroprotective HDAC6 inhibitor, tubastatin A.
Butler KV et al (2010) J Am Chem Soc 132(31) : 10842-6. -
Tubacin kills Epstein-Barr virus (EBV)-Burkitt lymphoma cells by inducing reactive oxygen species and EBV lymphoblastoid cells by inducing apoptosis.
Kawada J et al (2009) J Biol Chem 284(25) : 17102-9. -
Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation.
Haggarty SJ et al (2003) Proc Natl Acad Sci U S A 100(8) : 4389-94.
Selective HDAC6 inhibitor
![Tubacin [1350555-93-9] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb1403.png "Tubacin [1350555-93-9]")
Understanding purity and quality - a guide for life scientists