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Tranilast

(HB1201)
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Product overview

Name Tranilast
Purity >99%
Description TRPV2 channel inhibitor. Potent mast cell stabilizer.
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (4)
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Tranilast product vial image | Hello Bio
Tranilast product vial image | Hello Bio

Tranilast product vial image | Hello Bio

Tranilast product vial image | Hello Bio

Biological Data

Biological description TRPV2 channel inhibitor and potent mast cell stabilizer. Also inhibits angiotensin-II induced contractions (IC50 = 36 µM). Inhibits reactive oxygen species, cytokines, leukotrienes and prostaglandin release. Displays antiallergic, antiapoptotic and anti-inflammatory properties. Blood brain barrier permeable.

Solubility & Handling

Solubility overview Soluble in DMSO (100mM)
Storage instructions Room temperature
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >99%
Chemical name 2-[[3-(3,4-Dimethoxyphenyl)-1-oxo-2-propenyl]amino]benzoic acid
Molecular Weight 327.34
Chemical structure Tranilast [53902-12-8] Chemical Structure
Molecular Formula C18H17NO5
CAS Number 53902-12-8
PubChem identifier 5282230
SMILES COC1=C(C=C(C=C1)/C=C/C(=O)NC2=CC=CC=C2C(=O)O)OC
InChi InChI=1S/C18H17NO5/c1-23-15-9-7-12(11-16(15)24-2)8-10-17(20)19-14-6-4-3-5-13(14)18(21)22/h3-11H,1-2H3,(H,19,20)(H,21,22)/b10-8+
InChiKey NZHGWWWHIYHZNX-CSKARUKUSA-N
MDL number MFCD00864787

References for Tranilast

References are publications that support the biological activity of the product

  • Tranilast increases vasodilator response to acetylcholine in rat mesenteric resistance arteries through increased EDHF participation.

    Xavier FE et al (2014) PLoS One 9(7) : e100356.
    Read more (PubMedID: 24992476)

  • Tranilast binds to aβ monomers and promotes aβ fibrillation.

    Connors CR et al (2013) Biochemistry 52(23) : 3995-4002.
    Read more (PubMedID: 23679559)

  • Regulation of calcium-permeable TRPV2 channel by insulin in pancreatic beta-cells.

    Hisanaga E et al (2009) Diabetes 58(1) : 174-84.
    Read more (PubMedID: 18984736)

  • Tranilast, an anti-allergic drug, possesses antagonistic potency to angiotensin II.

    Jin D et al (1998) Eur J Pharmacol 361(2-3) : 199-205.
    Read more (PubMedID: 9865509)

4 Item(s)

Grouped product items
Order: HB1201
Pack PriceQty
10mg
$88
50mg
$325
TRPV2 channel inhibitor. Potent mast cell stabilizer.
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

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