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Images
Tranilast product vial image | Hello Bio
Tranilast product vial image | Hello Bio
Biological Data
| Biological description | TRPV2 channel inhibitor and potent mast cell stabilizer. Also inhibits angiotensin-II induced contractions (IC50 = 36 µM). Inhibits reactive oxygen species, cytokines, leukotrienes and prostaglandin release. Displays antiallergic, antiapoptotic and anti-inflammatory properties. Blood brain barrier permeable. |
Solubility & Handling
| Storage instructions | Room temperature |
| Solubility overview | Soluble in DMSO (100mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | 2-[[3-(3,4-Dimethoxyphenyl)-1-oxo-2-propenyl]amino]benzoic acid |
| Chemical structure | ![Tranilast [53902-12-8] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "Tranilast [53902-12-8]") |
| Molecular Formula | C18H17NO5 |
| PubChem identifier | 5282230 |
| SMILES | COC1=C(C=C(C=C1)/C=C/C(=O)NC2=CC=CC=C2C(=O)O)OC |
| InChi | InChI=1S/C18H17NO5/c1-23-15-9-7-12(11-16(15)24-2)8-10-17(20)19-14-6-4-3-5-13(14)18(21)22/h3-11H,1-2H3,(H,19,20)(H,21,22)/b10-8+ |
| InChiKey | NZHGWWWHIYHZNX-CSKARUKUSA-N |
References for Tranilast
References are publications that support the biological activity of the product
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Tranilast increases vasodilator response to acetylcholine in rat mesenteric resistance arteries through increased EDHF participation.
Xavier FE et al (2014) PLoS One 9(7) : e100356. -
Tranilast binds to aβ monomers and promotes aβ fibrillation.
Connors CR et al (2013) Biochemistry 52(23) : 3995-4002. -
Regulation of calcium-permeable TRPV2 channel by insulin in pancreatic beta-cells.
Hisanaga E et al (2009) Diabetes 58(1) : 174-84. -
Tranilast, an anti-allergic drug, possesses antagonistic potency to angiotensin II.
Jin D et al (1998) Eur J Pharmacol 361(2-3) : 199-205.
TRPV2 channel inhibitor. Potent mast cell stabilizer.
![Tranilast [53902-12-8] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb1201.png "Tranilast [53902-12-8]")
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