DREADD
Designer receptors exclusively activated by designer drugs (DREADDs) are genetically engineered GPCRs that are activated by physiologically inert synthetic small molecules (designer drugs) but not their endogenous ligand. Read our DREADDs mini-review or for practical advice on using these ligands in the lab see Stability of Water-Soluble DREADD Ligands in Solution: A Technical Review and Clozapine N-Oxide (freebase) - a technical review on stability, solubility and use in the lab).
RepSox (HB3301)
Description:Potent, selective TGF-βRI inhibitor. Enhances cellular reprogramming efficiency.
Purity:>99%
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Resveratrol (HB4055)
Description:Potent phenolic antioxidant with many biological actions. COX-1 inhibitor.
Purity:>98%
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RG 108 (HB1377)
Description:Non-nucleoside DNA methyltransferase inhibitor. Enhances iPSC generation efficiency.
Purity:>99%
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Riluzole (HB6093)
Description:Na+ channel blocker / glutamate inhibitor. TREK-1 K2P channel activator.
Purity:>98%
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Riluzole hydrochloride (HB0548)
Description:Na+ channel blocker / glutamate inhibitor. TREK-1 K2P channel activator. Water soluble.
Purity:>98%
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Ro 25-6981 maleate (HB0554)
Description:Selective negative allosteric modulator of GluN2B (NR2B) containing NMDARs
Purity:>98%
