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RN 1734

(HB1196)
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Product overview

Name RN 1734
Purity >98%
Description TRPV4 channel antagonist
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (2) Frequently bought together
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RN 1734 product vial image | Hello Bio
RN 1734 product vial image | Hello Bio

RN 1734 product vial image | Hello Bio

RN 1734 product vial image | Hello Bio

Biological Data

Biological description TRPV4 channel antagonist (IC50 values are 2.3, 3.2 and 5.9 µM for hTRPV4, rTRPV4 and mTRPV4). Exhibits higher selectivity for TRPV4 over TRPV1, TRPV3 and TRPM8 channels (IC50 values = >30 µM). Also blocks ATP-sensitive K+ channels.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in DMSO (100mM) and in ethanol (50mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name 2,4-Dichloro-N-isopropyl-N-(2-isopropylaminoethyl)benzenesulfonamide
Molecular Weight 353.31
Chemical structure RN 1734 [946387-07-1] Chemical Structure
Molecular Formula C14H22Cl2N2O2S
CAS Number 946387-07-1
PubChem identifier 3601086
SMILES CC(C)NCCN(C(C)C)S(=O)(=O)C1=C(C=C(C=C1)Cl)Cl
Source Sunthetic
InChi InChI=1S/C14H22Cl2N2O2S/c1-10(2)17-7-8-18(11(3)4)21(19,20)14-6-5-12(15)9-13(14)16/h5-6,9-11,17H,7-8H2,1-4H3
InChiKey IHYZMEAZAIFMTN-UHFFFAOYSA-N
MDL number MFCD00129453
Appearance White solid

References for RN 1734

References are publications that support the biological activity of the product

  • Low intravascular pressure activates endothelial cell TRPV4 channels, local Ca2+ events, and IKCa channels, reducing arteriolar tone.

    Bagher P et al (2012) Proc Natl Acad Sci U S A 109(44) : 18174-9.
    Read more (PubMedID: 23071308)

  • Identification and characterization of novel TRPV4 modulators.

    Vincent F et al (2009) Biochem Biophys Res Commun 389(3) : 490-4.
    Read more (PubMedID: 19737537)

2 Item(s)

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Grouped product items
Order: HB1196
Pack PriceQty
5mg
$59
25mg
$242
TRPV4 channel antagonist
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Hazardous: $35

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