Ro 25-6981 maleate

(HB0554)
Technical documents: SDS CoA Datasheet

Product overview

Name Ro 25-6981 maleate
Description Selective negative allosteric modulator of GluN2B (NR2B) containing NMDARs
Purity >98%
Write Your Own Review
You're reviewing:Ro 25-6981 maleate
Rate this item:

Biological Data

Biological description

Ro 25-6981 maleate is a selective negative allosteric modulator (NAM) of GluN2B (NR2B) containing NMDARs.

Ro 25-6981 maleate exhibits >5000-fold selectivity at GluN1C-GluN2B over GluN1C-GluN2A (IC50 values are 9 nM and 52 µM). Ro 25-6981 maleate shows neuroprotective properties.

Solubility & Handling

Storage instructions Room temperature (desiccate)
Solubility overview Soluble in water (10mM, gentle warming) and in DMSO (100mM)
Handling Hydroscopic solid, contact with air may cause material to become sticky. Product performance should not be affected but we recommend storing the material in a sealed jar.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

=
x
x
More Info

Dilution

x
=
x
More Info

Chemical Data

Chemical nameRS)-α-(4-Hydroxyphenyl)-β-methyl-4- (phenylmethyl)-1-piperidinepropanol maleate
Molecular Weight 455.55
Chemical structure Ro 25-6981  [1312991-76-6] Chemical Structure
Molecular Formula C22H29NO2.C4H4O4
CAS Number 1312991-76-6
PubChem identifier 53250677
SMILES C[C@@H](CN1CCC(CC1)CC2=CC=CC=C2)[C@H](C3=CC=C(C=C3)O)O.C(=C\C(=O)O)\C(=O)O
Source Synthetic
InChi InChI=1S/C22H29NO2.C4H4O4/c1-17(22(25)20-7-9-21(24)10-8-20)16-23-13-11-19(12-14-23)15-18-5-3-2-4-6-18;5-3(6)1-2-4(7)8/h2-10,17,19,22,24-25H,11-16H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t17-,22+;/m0./s1
InChiKey FYJZEHCQSUBZDY-SEELMCCHSA-N
MDL number MFCD06798375
Appearance White solid

References for Ro 25-6981 maleate

References are publications that support the biological activity of the product
  • The NR2B-selective NMDA receptor antagonist Ro 25-6981 potentiates the effect of nicotine on locomotor activity and DA release in the nucleus

    Kosowski AR et al (2004) J Pharmacol Exp Ther 311(2) : 560-7.
  • Pharmacological characterization of interactions of RO 25-6981 with the NR2B (epsilon2) subunit.

    Lynch DR et al (2001) Eur J Pharmacol 416(3) : 185-95.
  • Ro 25-6981, a highly potent and selective blocker of NMDA receptors containing the NR2B subunit. Characterization in vitro.

    Fischer G et al (1997) J Pharmacol Exp Ther 283(3) : 1285-92.
Publications
These publications cite the use of Ro 25-6981 maleate purchased from Hello Bio:
  • Differential Regulation of Evoked and Spontaneous Release by Presynaptic NMDA Receptors

    Abrahamsson et al (2017) Neuron 09 : 030
    PubMedID: 29033205

1 Item