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Ro 25-6981 maleate

(HB0554)
Publications (6)
Technical documents: SDS CoA Datasheet
5  Reviews
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Product overview

Name Ro 25-6981 maleate
Purity >98%
Description Selective negative allosteric modulator of GluN2B (NR2B) containing NMDARs
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (4) Reviews (5) Publications (6) References (3) Frequently bought together
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Ro 25-6981 maleate product vial image | Hello Bio
Ro 25-6981 maleate product vial image | Hello Bio

Ro 25-6981 maleate product vial image | Hello Bio

Ro 25-6981 maleate product vial image | Hello Bio

Biological Data

Biological description

Ro 25-6981 maleate is a selective negative allosteric modulator (NAM) of GluN2B (NR2B) containing NMDARs.

Ro 25-6981 maleate exhibits >5000-fold selectivity at GluN1C-GluN2B over GluN1C-GluN2A (IC50 values are 9 nM and 52 µM). Ro 25-6981 maleate shows neuroprotective properties.

Solubility & Handling

Storage instructions Room temperature (desiccate)
Solubility overview Soluble in water (10mM, gentle warming) and in DMSO (100mM)
Handling Hydroscopic solid, contact with air may cause material to become sticky. Product performance should not be affected but we recommend storing the material in a sealed jar.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name (αR,βS)-α-(4-Hydroxyphenyl)-β-methyl-4- (phenylmethyl)-1-piperidinepropanol maleate
Molecular Weight 455.55
Chemical structure Ro 25-6981 [1312991-76-6] Chemical Structure
Molecular Formula C22H29NO2.C4H4O4
CAS Number 1312991-76-6
PubChem identifier 53250677
SMILES C[C@@H](CN1CCC(CC1)CC2=CC=CC=C2)[C@H](C3=CC=C(C=C3)O)O.C(=C\C(=O)O)\C(=O)O
Source Synthetic
InChi InChI=1S/C22H29NO2.C4H4O4/c1-17(22(25)20-7-9-21(24)10-8-20)16-23-13-11-19(12-14-23)15-18-5-3-2-4-6-18;5-3(6)1-2-4(7)8/h2-10,17,19,22,24-25H,11-16H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t17-,22+;/m0./s1
InChiKey FYJZEHCQSUBZDY-SEELMCCHSA-N
MDL number MFCD06798375
Appearance White solid

References for Ro 25-6981 maleate

References are publications that support the biological activity of the product

  • The NR2B-selective NMDA receptor antagonist Ro 25-6981 potentiates the effect of nicotine on locomotor activity and DA release in the nucleus

    Kosowski AR et al (2004) J Pharmacol Exp Ther 311(2) : 560-7.
    Read more (PubMedID: 15256539)

  • Pharmacological characterization of interactions of RO 25-6981 with the NR2B (epsilon2) subunit.

    Lynch DR et al (2001) Eur J Pharmacol 416(3) : 185-95.
    Read more (PubMedID: 11290368)

  • Ro 25-6981, a highly potent and selective blocker of NMDA receptors containing the NR2B subunit. Characterization in vitro.

    Fischer G et al (1997) J Pharmacol Exp Ther 283(3) : 1285-92.
    Read more (PubMedID: 9400004)

3 Item(s)

Publications
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These publications cite the use of Ro 25-6981 maleate purchased from Hello Bio:

  • Chronic intermittent ethanol exposure disrupts stress-related tripartite communication to impact affect-related behavioral selection in male rats.

    Munier JJ et al (2023) Neurobiology of stress 24 : 100539
    PubMedID: 37131490

  • Synapse-specific burst coding sustained by local axonal translation.

    Wong HH et al (2023) Neuron
    PubMedID: 37944518

  • Local axonal translation sustains synapse-type-specific neurotransmission

    Sjöström et al (2022) Biorxiv : https://doi.org/10.1101/2022.06.27.497827

  • NMDA GluN2C/2D receptors contribute to synaptic regulation and plasticity in the anterior cingulate cortex of adult mice

    Chen QY et al (2021) Mol Brain 14(1) : 60
    PubMedID: 33766086

  • Effects of the GluN2B antagonist, Ro 25-6981, on extinction consolidation following adolescent- or adult-onset methamphetamine self-administration in male and female rats

    Westbrook SR et al (2020) Behav Pharmacol 31(8) : 748-758
    PubMedID: 32925228

Items 1 to 5 of 6 total

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Pack PriceQty
1mg
$61
10mg
$130
50mg
$540
Selective negative allosteric modulator of GluN2B (NR2B) containing NMDARs
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