Product overview

Name Risperidone
Alternative names R 64 766
Purity >99%
Description 5-HT2A and D2 receptor antagonist
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Biological Data

Biological description 5-HT2A and D2 receptor antagonist (Ki values are 0.4, 1.3, 6.7 and 7.5 nM at 5-HT2A , D2, D3 and D5 receptors respectively). Also shows affinity for α1 and α2 and H1 receptors. Atypical antipsychotic. Active in vivo.

Solubility & Handling

Storage instructions +4°C
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Purity >99%
Chemical name 3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-me thyl-4H-pyrido[1,2-a]pyrimidin-4-one
Molecular Weight 410.48
Chemical structure Risperidone  [106266-06-2] Chemical Structure
Molecular Formula C23H27FN4O2
CAS Number 106266-06-2
PubChem identifier 5073
SMILES FC1=CC2=C(C(C3CCN(CCC4=C(C)N=C(CCCC5)N5C4=O)CC3)=NO2)C=C1
InChiKey RAPZEAPATHNIPO-UHFFFAOYSA-N

References for Risperidone

References are publications that support the biological activity of the product
  • Antipsychotic drugs: importance of dopamine receptors for mechanisms of therapeutic actions and side effects.

    Strange PG (2001) Pharmacol Rev 53(1) : 119-33.
  • Long-term effects of olanzapine, risperidone, and quetiapine on dopamine receptor types in regions of rat brain: implications for antipsychotic drug treatment.

    Tarazi FI et al (2001) J Pharmacol Exp Ther 297(2) : 711-7.
  • Biochemical profile of risperidone, a new antipsychotic.

    Leysen JE et al (1988) J Pharmacol Exp Ther 247(2) : 661-70.

3 Item(s)