Product overview

Name Risperidone
Alternative names R 64 766
Purity >99%
Description 5-HT2A and D2 receptor antagonist
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Biological Data

Biological description 5-HT2A and D2 receptor antagonist (Ki values are 0.4, 1.3, 6.7 and 7.5 nM at 5-HT2A , D2, D3 and D5 receptors respectively). Also shows affinity for α1 and α2 and H1 receptors. Atypical antipsychotic. Active in vivo.

Solubility & Handling

Storage instructions +4°C
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Purity >99%
Chemical name 3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-me thyl-4H-pyrido[1,2-a]pyrimidin-4-one
Molecular Weight 410.48
Chemical structure Risperidone  [106266-06-2] Chemical Structure
Molecular Formula C23H27FN4O2
CAS Number 106266-06-2
PubChem identifier 5073
SMILES FC1=CC2=C(C(C3CCN(CCC4=C(C)N=C(CCCC5)N5C4=O)CC3)=NO2)C=C1
InChiKey RAPZEAPATHNIPO-UHFFFAOYSA-N

References for Risperidone

References are publications that support the biological activity of the product
  • Antipsychotic drugs: importance of dopamine receptors for mechanisms of therapeutic actions and side effects.

    Strange PG (2001) Pharmacol Rev 53(1) : 119-33.
  • Long-term effects of olanzapine, risperidone, and quetiapine on dopamine receptor types in regions of rat brain: implications for antipsychotic drug treatment.

    Tarazi FI et al (2001) J Pharmacol Exp Ther 297(2) : 711-7.
  • Biochemical profile of risperidone, a new antipsychotic.

    Leysen JE et al (1988) J Pharmacol Exp Ther 247(2) : 661-70.

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