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Riluzole hydrochloride

(HB0548)
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Technical documents: SDS CoA Datasheet
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Product overview

Name Riluzole hydrochloride
Alternative names PK 26124
Purity >98%
Description

Na+ channel blocker / glutamate inhibitor. TREK-1 K2P channel activator. Water soluble.

Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (6) Reviews (1) References (4) Frequently bought together
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Riluzole hydrochloride product vial image | Hello Bio
Riluzole hydrochloride product vial image | Hello Bio

Riluzole hydrochloride product vial image | Hello Bio

Riluzole hydrochloride product vial image | Hello Bio

Biological Data

Biological description

Na+ channel blocker. Increases glutamate uptake and inhibits glutamate release and also inhibits GABA uptake. Non-competitive NMDA receptor and Protein kinase C (PKC) inhibitor. Also a TREK-1 K2P channel activator. Shows neuroprotective, anxiolytic, anticonvulsant and anesthetic actions. Shows actions against motorneuron disease.

Solubility & Handling

Solubility overview Soluble in DMSO (100mM, gentle warming) and in water (10mM, gentle warming)
Storage instructions Room temperature
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name 2-Amino-6-trifluoromethoxybenzothiazole hydrochloride
Molecular Weight 270.66
Chemical structure Riluzole hydrochloride [850608-87-6] Chemical Structure
Molecular Formula C8H5F3N2OS.HCl
CAS Number 850608-87-6
PubChem identifier 6419992
SMILES C1=CC2=C(C=C1OC(F)(F)F)SC(=N2)N.Cl
Source Synthetic
InChi InChI=1S/C8H5F3N2OS.ClH/c9-8(10,11)14-4-1-2-5-6(3-4)15-7(12)13-5;/h1-3H,(H2,12,13);1H
InChiKey QEAOELIJQRYJJS-UHFFFAOYSA-N
MDL number MFCD00210213
Appearance White solid

References for Riluzole hydrochloride

References are publications that support the biological activity of the product

  • Riluzole improves outcome following ischemia-reperfusion injury to the spinal cord by preventing delayed paraplegia.

    Wu Y et al (2014) Neuroscience 265 : 302-12.
    Read more (PubMedID: 24508749)

  • Riluzole produces distinct anxiolytic-like effects in rats without the adverse effects associated with benzodiazepines.

    Sugiyama A et al (2012) Neuropharmacology 62(8) : 2489-98.
    Read more (PubMedID: 22377384)

  • Riluzole blocks persistent Na+ and Ca2+ currents and modulates release of glutamate via presynaptic NMDA receptors on neonatal rat hypoglossal motoneurons in vitro.

    Lamanauskas N et al (2008) Eur J Neurosci 27(10) : 2501-14.
    Read more (PubMedID: 18445055)

  • Riluzole enhances the activity of glutamate transporters GLAST, GLT1 and EAAC1.

    Fumagalli E et al (2008) Eur J Pharmacol 578(2-3) : 171-6.
    Read more (PubMedID: 18036519)

4 Item(s)

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Order: HB0548
Pack PriceQty
10mg
$37
50mg
$97

Na+ channel blocker / glutamate inhibitor. TREK-1 K2P channel activator. Water soluble.

Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

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