Product overview

Name Riluzole hydrochloride
Alternative names PK 26124
Purity >98%

Na+ channel blocker / glutamate inhibitor. TREK-1 K2P channel activator. Water soluble.

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Biological Data

Biological description

Na+ channel blocker. Increases glutamate uptake and inhibits glutamate release and also inhibits GABA uptake. Non-competitive NMDA receptor and Protein kinase C (PKC) inhibitor. Also a TREK-1 K2P channel activator. Shows neuroprotective, anxiolytic, anticonvulsant and anesthetic actions. Shows actions against motorneuron disease.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in DMSO (100mM, gentle warming) and in water (10mM, gentle warming)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >98%
Chemical name 2-Amino-6-trifluoromethoxybenzothiazole hydrochloride
Molecular Weight 270.66
Chemical structure Riluzole hydrochloride  [850608-87-6] Chemical Structure
Molecular Formula C8H5F3N2OS.HCl
CAS Number 850608-87-6
PubChem identifier 6419992
Source Synthetic
InChi InChI=1S/C8H5F3N2OS.ClH/c9-8(10,11)14-4-1-2-5-6(3-4)15-7(12)13-5;/h1-3H,(H2,12,13);1H
MDL number MFCD00210213
Appearance White solid

References for Riluzole hydrochloride

References are publications that support the biological activity of the product
  • Riluzole improves outcome following ischemia-reperfusion injury to the spinal cord by preventing delayed paraplegia.

    Wu Y et al (2014) Neuroscience 265 : 302-12.
  • Riluzole produces distinct anxiolytic-like effects in rats without the adverse effects associated with benzodiazepines.

    Sugiyama A et al (2012) Neuropharmacology 62(8) : 2489-98.
  • Riluzole blocks persistent Na+ and Ca2+ currents and modulates release of glutamate via presynaptic NMDA receptors on neonatal rat hypoglossal motoneurons in vitro.

    Lamanauskas N et al (2008) Eur J Neurosci 27(10) : 2501-14.
  • Riluzole enhances the activity of glutamate transporters GLAST, GLT1 and EAAC1.

    Fumagalli E et al (2008) Eur J Pharmacol 578(2-3) : 171-6.

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