My Cart
My account
Menu
Main Menu

Riluzole hydrochloride

(HB0548)
Be the first to add a publication
Technical documents: SDS CoA Datasheet
1  Review
Top Reviews:
100% of 100
Add Your Review
Add to Wish List

Product overview

Name Riluzole hydrochloride
Alternative names PK 26124
Purity >98%
Description

Na+ channel blocker / glutamate inhibitor. TREK-1 K2P channel activator. Water soluble.

Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (6) Reviews (1) References (4) Frequently bought together
Write Your Own Review
You're reviewing:Riluzole hydrochloride
Rate this item:

Images

Riluzole hydrochloride product vial image | Hello Bio
Riluzole hydrochloride product vial image | Hello Bio

Riluzole hydrochloride product vial image | Hello Bio

Riluzole hydrochloride product vial image | Hello Bio

Biological Data

Biological description

Na+ channel blocker. Increases glutamate uptake and inhibits glutamate release and also inhibits GABA uptake. Non-competitive NMDA receptor and Protein kinase C (PKC) inhibitor. Also a TREK-1 K2P channel activator. Shows neuroprotective, anxiolytic, anticonvulsant and anesthetic actions. Shows actions against motorneuron disease.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in DMSO (100mM, gentle warming) and in water (10mM, gentle warming)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

=
x
x
More Info

Dilution

x
=
x
More Info

Chemical Data

Purity >98%
Chemical name 2-Amino-6-trifluoromethoxybenzothiazole hydrochloride
Molecular Weight 270.66
Chemical structure Riluzole hydrochloride [850608-87-6] Chemical Structure
Molecular Formula C8H5F3N2OS.HCl
CAS Number 850608-87-6
PubChem identifier 6419992
SMILES C1=CC2=C(C=C1OC(F)(F)F)SC(=N2)N.Cl
Source Synthetic
InChi InChI=1S/C8H5F3N2OS.ClH/c9-8(10,11)14-4-1-2-5-6(3-4)15-7(12)13-5;/h1-3H,(H2,12,13);1H
InChiKey QEAOELIJQRYJJS-UHFFFAOYSA-N
MDL number MFCD00210213
Appearance White solid

References for Riluzole hydrochloride

References are publications that support the biological activity of the product

  • Riluzole improves outcome following ischemia-reperfusion injury to the spinal cord by preventing delayed paraplegia.

    Wu Y et al (2014) Neuroscience 265 : 302-12.
    Read more (PubMedID: 24508749)

  • Riluzole produces distinct anxiolytic-like effects in rats without the adverse effects associated with benzodiazepines.

    Sugiyama A et al (2012) Neuropharmacology 62(8) : 2489-98.
    Read more (PubMedID: 22377384)

  • Riluzole blocks persistent Na+ and Ca2+ currents and modulates release of glutamate via presynaptic NMDA receptors on neonatal rat hypoglossal motoneurons in vitro.

    Lamanauskas N et al (2008) Eur J Neurosci 27(10) : 2501-14.
    Read more (PubMedID: 18445055)

  • Riluzole enhances the activity of glutamate transporters GLAST, GLT1 and EAAC1.

    Fumagalli E et al (2008) Eur J Pharmacol 578(2-3) : 171-6.
    Read more (PubMedID: 18036519)

4 Item(s)

Related Products
Grouped product items
Order: HB0548
Pack PriceQty
10mg
$36
50mg
$94

Na+ channel blocker / glutamate inhibitor. TREK-1 K2P channel activator. Water soluble.

Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

Contact Us

Call 609-683-7500
Fax 609-228-4994

customercare-usa@hellobio.com

New Products in this Area

ML 335
HB6763
Selective K2P2.1 (TREK-1) and K2P10.1 (TREK-2) activator
ML 336 (K2P2.1/ TREK-1 modulator)
HB7386
Covalent K2P2.1 (TREK-1) modulator
CAT335
HB8146
K2P2.1 (TREK-1) modulator. Selectively and irreversibly activates TREK-1CG* but not wild-type K2P2.1 (TREK-1)

Related Products

NMDA
Code:
HB0454
Pack:
50mg, 250mg, 1g, 5g, 100mM (add 1ml water)
Price:
$69, $332, $728, $2.879, $50
Prototypic NMDA receptor agonist
(S)-AMPA
Code:
HB0052
Pack:
1mg, 5mg, 10mg, 50mg
Price:
$98, $143, $234, $931
AMPA receptor agonist
D-AP5
Code:
HB0225
Pack:
1mg, 10mg, 50mg, 100mg, 50mM (add 1ml water), 100mM (add 1ml water)
Price:
$45, $116, $495, $685, $161, $289
(Free trial)

Selective, competitive NMDA receptor antagonist. Inhibits NMDAR-synaptic plasticity.