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Biological Data Biological description Vesicular monoamine re-uptake blocker. Irreversibly binds VMAT2 to deplete synaptic monoamines. Produces depression-like effects and shows antipsychotic and antihypertensive effects.
Solubility & Handling Storage instructions Room temperature
Solubility overview Soluble in DMSO (10 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name (3β,16β,17α,18β,20α)-11,17-Dimethoxy-18- [(3,4,5-trimethoxybenzoyl)oxy]yohimban-16-carboxyl ic acid methyl ester
Chemical structure
Molecular Formula C33 H40 N2 O9
SMILES CO[C@H]1[C@@H](C[C@@H]2CN3CCC4=C([C@H]3C[C@@H]2[C@@H]1C(=O)OC)NC5=C4C=CC(=C5)OC)OC(=O)C6=CC(=C(C(=C6)OC)OC)OC
InChi InChI=1S/C33H40N2O9/c1-38-19-7-8-20-21-9-10-35-16-18-13-27(44-32(36)17-11-25(39-2)30(41-4)26(12-17)40-3)31(42-5)28(33(37)43-6)22(18)15-24(35)29(21)34-23(20)14-19/h7-8,11-12,14,18,22,24,27-28,31,34H,9-10,13,15-16H2,1-6H3/t18-,22+,24-,27-,28+,31+/m1/s1
InChiKey QEVHRUUCFGRFIF-MDEJGZGSSA-N
References for Reserpine References are publications that support the biological activity of the product
Antidepressant-like effect of tetrahydroisoquinoline amines in the animal model of depressive disorder induced by repeated administration of a low dose of reserpine: behavioral and neurochemical studies in the rat. Antkiewicz-Michaluk L et al (2014) Neurotox Res 26(1) : 85-98. Reserpine binding to a vesicular amine transporter expressed in Chinese hamster ovary fibroblasts. Schuldiner S et al (1993) J Biol Chem 268(1) : 29-34. Radioligands of the vesicular monoamine transporter and their use as markers of monoamine storage vesicles. Henry JP et al (1989) Biochem Pharmacol 38(15) : 2395-404.
Vesicular monoamine re-uptake blocker
![Reserpine [50-55-5] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb1895.png "Reserpine [50-55-5]")
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