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Riluzole

(HB6093)
Publications (3)
Technical documents: SDS CoA Datasheet
2  Reviews
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Product overview

Name Riluzole
Alternative names PK 26124
Purity >98%
Customer comments

Great quality by half the price of other suppliers. We have been using riluzole from regular suppliers for many years. Now, we have tested Riluzole from Hello Bio and this has worked fantastic. Compound activity is comparable to the previous one, but the price is almost half of it. Also, the user experience working with them is easy and fast. I definitely recommend this compound. Verified customer, University of Vigo

Description

Na+ channel blocker / glutamate inhibitor. TREK-1 K2P channel activator.

Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (4) Reviews (2) Publications (3) References (4) Frequently bought together
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Biological Data

Biological description

Na+ channel blocker. Increases glutamate uptake, inhibits glutamate release and inhibits GABA uptake. Non-competitive NMDA receptor and Protein kinase C (PKC) inhibitor and a TREK-1 K2P channel activator. Shows neuroprotective, anxiolytic, anticonvulsant and anesthetic actions. Shows actions against motorneuron disease.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in DMSO (100 mM), and in ethanol (100 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name 2-Amino-6-(trifluoromethoxy)benzothiazole
Molecular Weight 234.2
Chemical structure Riluzole [1744-22-5] Chemical Structure
Molecular Formula C8H5F3N2OS
CAS Number 1744-22-5
PubChem identifier 5070
SMILES C1=CC2=C(C=C1OC(F)(F)F)SC(=N2)N
InChi InChI=1S/C8H5F3N2OS/c9-8(10,11)14-4-1-2-5-6(3-4)15-7(12)13-5/h1-3H,(H2,12,13)
InChiKey FTALBRSUTCGOEG-UHFFFAOYSA-N
MDL number MFCD00210213
Appearance White solid

References for Riluzole

References are publications that support the biological activity of the product

  • Riluzole improves outcome following ischemia-reperfusion injury to the spinal cord by preventing delayed paraplegia.

    Wu Y et al (2014) Neuroscience 265 : 302-12.
    Read more (PubMedID: 24508749)

  • Riluzole produces distinct anxiolytic-like effects in rats without the adverse effects associated with benzodiazepines.

    Sugiyama A et al (2012) Neuropharmacology 62(8) : 2489-98.
    Read more (PubMedID: 22377384)

  • Riluzole blocks persistent Na+ and Ca2+ currents and modulates release of glutamate via presynaptic NMDA receptors on neonatal rat hypoglossal motoneurons in vitro.

    Lamanauskas N et al (2008) Eur J Neurosci 27(10) : 2501-14.
    Read more (PubMedID: 18445055)

  • Riluzole enhances the activity of glutamate transporters GLAST, GLT1 and EAAC1.

    Fumagalli E et al (2008) Eur J Pharmacol 578(2-3) : 171-6.
    Read more (PubMedID: 18036519)

4 Item(s)

Publications
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These publications cite the use of Riluzole purchased from Hello Bio:

  • Modulating voltage-gated sodium channels to enhance differentiation and sensitize glioblastoma cells to chemotherapy.

    Giammello F et al (2024) Cell communication and signaling : CCS 22 : 434
    PubMedID: 39251990

  • Activation of TREK currents by riluzole in three subgroups of cultured mouse nodose ganglion neurons

    Fernández-Fernández D, Cadaveira-Mosquera A, Rueda-Ruzafa L, Herrera-Pérez S, Veale EL, Reboreda A, Mathie A, Lamas JA. (2018) Plos ONE 13(6) : e0199282
    PubMedID: 29928032

  • The Role of Synaptic Inhibition in the Primary Motor Cortex of an ALS Mouse Model

    Place, KM (2018) Thesis Nov : -2018

3 Item(s)

Related Products
Grouped product items
Order: HB6093
Pack PriceQty
10mg
$33
50mg
$95
250mg
$365

Na+ channel blocker / glutamate inhibitor. TREK-1 K2P channel activator.

Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

Contact Us

Call 609-683-7500
Fax 609-228-4994

customercare-usa@hellobio.com

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