Riluzole

(HB6093)
Technical documents: SDS CoA Datasheet

Product overview

Name Riluzole
Description Na+ channel blocker / glutamate inhibitor
Biological description Na+ channel blocker. Increases glutamate uptake and inhibits glutamate release. Also inhibits GABA uptake. Non-competitive NMDA receptor and Protein kinase C (PKC) inhibitor. Shows neuroprotective, anxiolytic, anticonvulsant and anesthetic actions. Shows actions against motorneuron disease.
Alternative names PK 26124
Purity >98%
Customer comments

Great quality by half the price of other suppliers. We have been using riluzole from regular suppliers for many years. Now, we have tested Riluzole from Hello Bio and this has worked fantastic. Compound activity is comparable to the previous one, but the price is almost half of it. Also, the user experience working with them is easy and fast. I definitely recommend this compound. Verified customer, University of Vigo

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Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in DMSO (100 mM), and in ethanol (100 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Chemical name 2-Amino-6-(trifluoromethoxy)benzothiazole
Molecular Weight 234.2
Chemical structure Product image
Molecular Formula C8H5F3N2OS
CAS Number 1744-22-5
PubChem identifier 5070
SMILES C1=CC2=C(C=C1OC(F)(F)F)SC(=N2)N
InChi InChI=1S/C8H5F3N2OS/c9-8(10,11)14-4-1-2-5-6(3-4)15-7(12)13-5/h1-3H,(H2,12,13)
InChiKey FTALBRSUTCGOEG-UHFFFAOYSA-N
MDL number MFCD00210213
Appearance White solid

References for Riluzole

References are publications that support the biological activity of the product
  • Riluzole produces distinct anxiolytic-like effects in rats without the adverse effects associated with benzodiazepines.

    Sugiyama A et al (2012) Neuropharmacology 62(8) : 2489-98.
  • Riluzole blocks persistent Na+ and Ca2+ currents and modulates release of glutamate via presynaptic NMDA receptors on neonatal rat hypoglossal motoneurons in vitro.

    Lamanauskas N et al (2008) Eur J Neurosci 27(10) : 2501-14.
  • Riluzole enhances the activity of glutamate transporters GLAST, GLT1 and EAAC1.

    Fumagalli E et al (2008) Eur J Pharmacol 578(2-3) : 171-6.
  • Riluzole improves outcome following ischemia-reperfusion injury to the spinal cord by preventing delayed paraplegia.

    Wu Y et al (2014) Neuroscience 265 : 302-12.
Publications
These publications cite the use of Riluzole purchased from Hello Bio:
  • Activation of TREK currents by riluzole in three subgroups of cultured mouse nodose ganglion neurons

    Fernández-Fernández D, Cadaveira-Mosquera A, Rueda-Ruzafa L, Herrera-Pérez S, Veale EL, Reboreda A, Mathie A, Lamas JA. (2018) Plos ONE 13(6) : e0199282
    PubMedID: 29928032
  • The Role of Synaptic Inhibition in the Primary Motor Cortex of an ALS Mouse Model

    Place, KM (2018) Thesis Nov : -2018

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