Potent, selective TGF-βRI/ALK5 inhibitor (IC50 values are 4 and 23 nM TGF-βRI autophosphorylation and binding respectively. Selective for TGF-βRI/ compared to a range of kinases (p38 MAPK, GSK-3, JNK1).
Enhances cellular reprogramming efficiency by replacing the Sox2 factor by inducing Nanog expression
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Solubility & Handling
Solubility overview
Soluble in DMSO (100mM) or ethanol (50mM)
Storage instructions
+4°C
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Y-27632 is a selective ROCK inhibitor. Frequently used 3D growth matrix component and for production of organoids. Also used when inducing neurons from fibroblasts. Manufactured to a high degree of optical purity.
![RepSox | E-616452, SJN 2511, ALK5 Inhibitor II [446859-33-2] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb3301.png "RepSox | E-616452, SJN 2511, ALK5 Inhibitor II [446859-33-2]")
Understanding purity and quality - a guide for life scientists
