Product overview
| Name | RG 108 |
| Description | Non-nucleoside DNA methyltransferase inhibitor. Enhances iPSC generation efficiency. |
| Purity | >99% |
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Biological Data
| Biological description | Non-nucleoside DNA methyltransferase (DNMT) inhibitor (IC50 = 115 nM). Binds at the active site. Causes hypomethylation and reactivates tumor suppressor genes. Shows growth inhibiting and pro-apoptotic anti-cancer actions. Also enhances iPSC generation efficiency. |
Solubility & Handling
| Storage instructions | Room temperature |
| Solubility overview | Soluble in DMSO (100mM) or ethanol (100mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | N-Phthalyl-L-tryptophan |
| Molecular Weight | 334.33 |
| Chemical structure | ![RG 108 [48208-26-0] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb1377.png "RG 108 [48208-26-0]") |
| Molecular Formula | C19H14N2O4 |
| CAS Number | 48208-26-0 |
| PubChem identifier | 702558 |
| SMILES | O=C(C(C=CC=C4)=C4C3=O)N3[C@H](C(O)=O)CC2=CNC1=CC=CC=C12 |
| InChiKey | HPTXLHAHLXOAKV-INIZCTEOSA-N |
References for RG 108
References are publications that support the biological activity of the product
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Anti-tumoral effect of the non-nucleoside DNMT inhibitor RG108 in human prostate cancer cells.
Graã?a I et al (2014) Curr Pharm Des 20(11) : 1803-11. -
Functional diversity of DNA methyltransferase inhibitors in human cancer cell lines.
Stresemann C et al (2006) Cancer Res 66(5) : 2794-800. -
Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human DNA methyltransferases.
Brueckner B et al (2005) Cancer Res 65(14) : 6305-11.
Publications
These publications cite the use of RG 108 purchased from Hello Bio:
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Regulación epigenética de la condrogénesis y la muerte celular programada durante el desarrollo embrionario de las extremidades
Sánchez Fernández, C. (2020) Universidad de Cantabria Thesis : 1-246
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