Product overview

Name RG 108
Description Non-nucleoside DNA methyltransferase inhibitor. Enhances iPSC generation efficiency.
Purity >99%
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Biological Data

Biological description Non-nucleoside DNA methyltransferase (DNMT) inhibitor (IC50 = 115 nM). Binds at the active site. Causes hypomethylation and reactivates tumor suppressor genes. Shows growth inhibiting and pro-apoptotic anti-cancer actions. Also enhances iPSC generation efficiency.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in DMSO (100mM) or ethanol (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Chemical name N-Phthalyl-L-tryptophan
Molecular Weight 334.33
Chemical structure RG 108  [48208-26-0] Chemical Structure
Molecular Formula C19H14N2O4
CAS Number 48208-26-0
PubChem identifier 702558
SMILES O=C(C(C=CC=C4)=C4C3=O)N3[C@H](C(O)=O)CC2=CNC1=CC=CC=C12
InChiKey HPTXLHAHLXOAKV-INIZCTEOSA-N

References for RG 108

References are publications that support the biological activity of the product
  • Anti-tumoral effect of the non-nucleoside DNMT inhibitor RG108 in human prostate cancer cells.

    Graã?a I et al (2014) Curr Pharm Des 20(11) : 1803-11.
  • Functional diversity of DNA methyltransferase inhibitors in human cancer cell lines.

    Stresemann C et al (2006) Cancer Res 66(5) : 2794-800.
  • Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human DNA methyltransferases.

    Brueckner B et al (2005) Cancer Res 65(14) : 6305-11.
Publications
These publications cite the use of RG 108 purchased from Hello Bio:
  • Regulación epigenética de la condrogénesis y la muerte celular programada durante el desarrollo embrionario de las extremidades

    Sánchez Fernández, C. (2020) Universidad de Cantabria Thesis : 1-246

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