Histone deacetylase (HDAC)

Histone acetylation is a key epigenetic process - it is upregulated during memory formation but downregulated in numerous neurodegenerative diseases (eg. Alzheimer's disease and Huntington's disease). There are 18 Histone Deacetylase (HDAC) enzymes that are classified into two groups, the histone deacetylase family and the sirtuin family. The histone deacetylase family is further divided into classes I, II and IV. HDAC inhibitors are a class of compounds that increase acetylation of lysine residues on histone proteins as well as other, nonhistone, proteins by inhibiting the activity of these HDAC enzymes. Researchers can save up to 50% on HDAC inhibitors from Hello Bio - they are up to half the price of other suppliers.

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Items 181-190 of 191

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  1. VX 702 (HB1308)

    Description:

    Potent, selective ATP-competitive p38 MAPK inhibitor

    Purity:

    >98%

    Pack:
    10mg
    Price:
    $161
    Qty:
  2. VX 745 (HB1309)

    Description:

    Potent, selective p38α MAPK inhibitor

    Purity:

    >98%

    Pack:
    10mg
    Price:
    $213
    Qty:
    Pack:
    50mg
    Price:
    $822
    Qty:
  3. Wedelolactone (HB4124)

    Description:

    Selective IKKα and IKKβ kinase activity inhibitor. NF-κB inhibitor.

    Purity:

    >98%

    Pack:
    1mg
    Price:
    $134
    Qty:
    Pack:
    5mg
    Price:
    $384
    Qty:
  4. WHI-P 154 (HB1431)

    Description:

    Non-selective JAK3 inhibitor and potent EGFR inhibitor. Induces neural progenitor cell differentiation.

    Purity:

    >99%

    Pack:
    5mg
    Price:
    $85
    Qty:
    Pack:
    25mg
    Price:
    $307
    Qty:
  5. Wortmannin (HB2778)

    1  Review
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    Description:

    Potent, selective, irreversible PI3-K inhibitor

    Purity:

    >99%

    Pack:
    1mg
    Price:
    Qty:
    Pack:
    5mg
    Price:
    $257
    Qty:
    Pack:
    10mg
    Price:
    $475
    Qty:
  6. X-Gal (HB4128)

    Description:

    Detects presence and activity of β -galactosidase. Widely used in cloning applications.

    Purity:

    >99%

    Pack:
    50mg
    Price:
    $30
    Qty:
    Pack:
    250mg
    Price:
    $46
    Qty:
  7. 9  Reviews
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    Description:

    Y-27632 is a selective ROCK inhibitor. Frequently used 3D growth matrix component and for production of organoids. Also used when inducing neurons from fibroblasts. Manufactured to a high degree of optical purity.

    Purity:

    >99%

    Pack:
    1mg
    Price:
    $46
    Qty:
    Pack:
    2mg
    Price:
    Qty:
    Pack:
    5mg
    Price:
    $124
    Qty:
    Pack:
    10mg
    Price:
    $175
    Qty:
    Pack:
    5x10mg
    Price:
    $786
    Qty:
    Pack:
    25mg
    Price:
    $339
    Qty:
    Pack:
    50mg
    Price:
    $588
    Qty:
    Pack:
    10mM solution (in 1mL DMSO)
    Price:
    $180
    Qty:
    Pack:
    50mM (add 1ml water)
    Price:
    $426
    Qty:
    Pack:
    100mM (add 1ml water)
    Price:
    $710
    Qty:
  8. Zerumbone (HB4130)

    Description:

    Apoptosis inducer. Modulates NF-κB activation.

    Purity:

    >99%

    Pack:
    10mg
    Price:
    $75
    Qty:
    Pack:
    50mg
    Price:
    $284
    Qty:
  9. Pack:
    1mg
    Price:
    $205
    Qty:
    Pack:
    5mg
    Price:
    $708
    Qty:
  10. Pack:
    1mg
    Price:
    $212
    Qty:
    Pack:
    5mg
    Price:
    $511
    Qty:
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