Potent and selective ATP-competitive p38 MAPK inhibitor (Kd values are 3.7 and 17 nM for p38α and p38β respectively). Also inhibits production of IL-6, IL-1β and TNFα (IC50 values are 59, 122 and 99 ng/ml respectively). Exhibits no activity for ERKs and JNKs Displays anti-inflammatory properties.
Solubility & Handling
Soluble in DMSO (100mM)
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.