Potent and selective ATP-competitive p38 MAPK inhibitor (Kd values are 3.7 and 17 nM for p38α and p38β respectively). Also inhibits production of IL-6, IL-1β and TNFα (IC50 values are 59, 122 and 99 ng/ml respectively). Exhibits no activity for ERKs and JNKs Displays anti-inflammatory properties.
Solubility & Handling
Solubility overview
Soluble in DMSO (100mM)
Storage instructions
+4°C
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Understanding purity and quality - a guide for life scientists