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Images Z-VAD-(OMe)-FMK product vial image | Hello Bio
Z-VAD-(OMe)-FMK product vial image | Hello Bio Biological Data Biological description Irreversible, cell permeable, broad spectrum caspase inhibitor. Also inhibits PARP-1 cleavage and Fas-induced apoptosis. Hydrolysed by endogenous esterases into the biologically active form Z-VAD-FMK.
Solubility & Handling Storage instructions -20°C
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name Benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone
Chemical structure
Molecular Formula C22 H30 FN3 O7
PubChem identifier 5497174
SMILES C[C@@H](C(=O)N[C@@H](CC(=O)OC)C(=O)CF)NC(=O)[C@H](C(C)C)NC(=O)OCC1=CC=CC=C1
InChi InChI=1S/C22H30FN3O7/c1-13(2)19(26-22(31)33-12-15-8-6-5-7-9-15)21(30)24-14(3)20(29)25-16(17(27)11-23)10-18(28)32-4/h5-9,13-14,16,19H,10-12H2,1-4H3,(H,24,30)(H,25,29)(H,26,31)/t14-,16-,19-/m0/s1
InChiKey MIFGOLAMNLSLGH-QOKNQOGYSA-N
References for Z-VAD-(OMe)-FMK References are publications that support the biological activity of the product
Amyloid precursor protein binding protein Fe65 is cleaved by caspases during DNA damage-induced apoptosis. Saeki K et al (2011) Biol Pharm Bull 34(2) : 290-4. A specific inhibitor of apoptosis decreases tissue injury after intestinal ischemia-reperfusion in mice. Farber A et al (1999) J Vasc Surg 30(4) : 752-60. Benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone (Z-VAD.FMK) inhibits apoptosis by blocking the processing of CPP32. Slee EA et al (1996) Biochem J 315 ( Pt 1) : 21-4.
Irreversible, cell permeable, broad spectrum caspase inhibitor.
![Z-VAD-(OMe)-FMK [187389-52-2] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb_1319.png "Z-VAD-(OMe)-FMK [187389-52-2]")
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