Potent and selective p38α MAPK inhibitor. Exhibits 20-fold selectivity for p38α over p38β (Ki = 200 nM). Shows little or no activity at other MAP kinases. Inhibits TNFα and IL-1β (IC50 values are 45 and 51 nM respectively). Displays anti-inflammatory properties.
Solubility & Handling
Solubility overview
Soluble in DMSO (100mM)
Storage instructions
-20°C
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Understanding purity and quality - a guide for life scientists