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VX 745

(HB1309)
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Technical documents: SDS Datasheet

Product overview

Name VX 745
Purity >98%
Description Potent, selective p38α MAPK inhibitor
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (2)
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Biological Data

Biological description Potent and selective p38α MAPK inhibitor. Exhibits 20-fold selectivity for p38α over p38β (Ki = 200 nM). Shows little or no activity at other MAP kinases. Inhibits TNFα and IL-1β (IC50 values are 45 and 51 nM respectively). Displays anti-inflammatory properties.

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name 5-(2,6-Dichlorophenyl)-2-[2,4-difluorophenyl)thio]-6H-pyrimido[1,6-b]pyridazin-6-one
Molecular Weight 436.26
Molecular Formula C19H9Cl2F2N3OS
CAS Number 209410-46-8
PubChem identifier 3038525
SMILES O=C2N=CN1N=C(SC4=CC=C(F)C=C4F)C=CC1=C2C3=C(Cl)C=CC=C3Cl
InChiKey VEPKQEUBKLEPRA-UHFFFAOYSA-N

References for VX 745

References are publications that support the biological activity of the product

  • The Discovery of VX-745: A Novel and Selective p38α Kinase Inhibitor.

    Duffy JP et al (2011) ACS Med Chem Lett 2(10) : 758-63.
    Read more (PubMedID: 24900264)

  • Rapid synthesis of VX-745: p38 MAP kinase inhibition in Werner syndrome cells.

    Bagley MC et al (2007) Bioorg Med Chem Lett 17(18) : 5107-10.
    Read more (PubMedID: 17659871)

2 Item(s)

Grouped product items
Order: HB1309
Pack PriceQty
10mg
$211
50mg
$814
Potent, selective p38α MAPK inhibitor
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