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Biological Data
| Biological description | Cell permeable, selective and irreversible IKKalpha and beta kinase activity inhibitor. NF-kappaB inhibitor. Blocks phosphorylation and degradation of IkappaBalpha. Antihepatotoxic. 5-Lipoxygenase (5-LOX) inhibitor. Anti-inflammatory. HIV-1 integrase inhibitor. Anticancer and antiproliferative compound. Modulates androgen receptor (AR) activation. Apoptosis inducer via downregulation of PKCepsilon. DNA topoisomerase IIalpha inhibitor. G protein-coupled receptor-35 (GPR35) agonist. Inhibits adipogenic differentiation of mesenchymal stem cells (hAMSCs) through ERK pathway. STAT1 protein dephosphorylation inhibitor. Antifibrotic. |
Solubility & Handling
| Storage instructions | +4°C |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | 7-Methoxy-5,11,12-trihydroxy-coumestan |
| Chemical structure | ![Wedelolactone [524-12-9] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "Wedelolactone [524-12-9]") |
| SMILES | COc1cc(O)c2c(OC(=O)c3c2oc4cc(O)c(O)cc34)c1 |
| InChiKey | XQDCKJKKMFWXGB-UHFFFAOYSA-N |
| Appearance | Yellow to amber crystalline powder |
Selective IKKα and IKKβ kinase activity inhibitor. NF-κB inhibitor.
![Wedelolactone [524-12-9] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb4124.png "Wedelolactone [524-12-9]")
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