Product overview

Name Wedelolactone
Purity >98%
Description Selective IKKα and IKKβ kinase activity inhibitor. NF-κB inhibitor.
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Biological Data

Biological description Cell permeable, selective and irreversible IKKalpha and beta kinase activity inhibitor. NF-kappaB inhibitor. Blocks phosphorylation and degradation of IkappaBalpha. Antihepatotoxic. 5-Lipoxygenase (5-LOX) inhibitor. Anti-inflammatory. HIV-1 integrase inhibitor. Anticancer and antiproliferative compound. Modulates androgen receptor (AR) activation. Apoptosis inducer via downregulation of PKCepsilon. DNA topoisomerase IIalpha inhibitor. G protein-coupled receptor-35 (GPR35) agonist. Inhibits adipogenic differentiation of mesenchymal stem cells (hAMSCs) through ERK pathway. STAT1 protein dephosphorylation inhibitor. Antifibrotic.

Solubility & Handling

Storage instructions +4°C
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Chemical Data

Purity >98%
Chemical name 7-Methoxy-5,11,12-trihydroxy-coumestan
Molecular Weight 314.2
Chemical structure Wedelolactone [524-12-9] Chemical Structure
CAS Number 524-12-9
SMILES COc1cc(O)c2c(OC(=O)c3c2oc4cc(O)c(O)cc34)c1
InChiKey XQDCKJKKMFWXGB-UHFFFAOYSA-N
Appearance Yellow to amber crystalline powder